… cells, this kinase has been viewed as an excellent therapeutic target for the development of
a … about the feasibility and effectiveness of targeting Janus kinases, and it appears likely that …

… As reported recently, critically ill COVID‐19 patients show genetic polymorphisms in one
IFN receptor gene (IFNRA2) and in a gene locus near the Janus kinase (JAK) TYK2, which is …

… The Janus kinases or JAKs are a family of intracellular tyrosine kinases that play an essential
role in the signaling of numerous cytokines that have been implicated in the pathogenesis …

Hyperactive Janus associated kinase–signal transducers and activators of transcription (JAK–STAT)
signaling has been shown to be integral to the pathogenesis of myelofibrosis (MF) …

… potentially serve as therapeutic targets [11]. To identify therapeutic targets beyond cytokines
… We also propose and summarize potential novel therapeutic targets beyond those of current …

… Janus kinase (Jak) 2, growth factor receptor binding protein 2–associated binder (Gab) 2, Akt,
and glycogen synthase kinase (… Jak2 as a potentially important therapeutic target for CML. (…

The four Janus kinase (JAK) proteins and seven signal transducer and activator of transcription
(STAT) transcription factors mediate intracellular signal transduction downstream of …

… specific therapeutic targets … Janus Kinase inhibitor (JAKi), tofacitinib, for the treatment of RA.
In 2017, tofacitinib and another JAKi, baricitinib, received approval in Europe. Janus Kinases …

… janus-faced molecule and acts as a double-edged sword in vascular complications in diabetes.
► In this paper, we review the janus… and activity is a therapeutic target for diabetic micro- …

… JAK3 KINASE The present review will focus on one particular Janus kinase family member
… In contrast to the relatively ubiquitous expression of JAK1, JAK2 and TYK2 kinases in many …