Review on therapeutic targets for COVID-19: insights from cytokine storm

ML de Mélo Silva Júnior, LMA de Souza… - Postgraduate …, 2021 - academic.oup.com
… that release cytokines (notably IL-1, IL-6 and TNF) and … (cytokine storm) and tissue damage.
Some drugs have been studied as therapeutic targets (block to viral entry or to cytokine storm

Targeting the “cytokine storm” for therapeutic benefit

RV D'Elia, K Harrison, PC Oyston… - Clinical and Vaccine …, 2013 - Am Soc Microbiol
… life-threatening “cytokine storms” in the host … cytokine storms which may prove useful in
the clinic in the future and compare them to more traditional therapeutic candidates that target

The 'cytokine storm': molecular mechanisms and therapeutic prospects

R Karki, TD Kanneganti - Trends in immunology, 2021 - cell.com
Cytokine storm syndrome (CSS) has generally been described as a collection of clinical
manifestations resulting from an overactivated immune system. Cytokine stormstherapeutic

Immunoregulatory therapy strategies that target cytokine storms in patients with COVID‑19

X Wang, Z He, X Zhao - Experimental and Therapeutic …, 2021 - spandidos-publications.com
… Immunoregulatory therapies target the cytokine storms induced by severe acute respiratory
syndrome coronavirus 2 (SARS‑CoV‑2), the virus that causes COVID‑19, and include …

[HTML][HTML] Hazards of the cytokine storm and cytokine-targeted therapy in patients with COVID-19

M Quirch, J Lee, S Rehman - Journal of medical Internet research, 2020 - jmir.org
… Here, we present a literature review regarding current and potential pharmacologic
treatments that specifically aim to target the cytokine storm in the battle against COVID-19. …

Pathogenesis and treatment of cytokine storm induced by infectious diseases

XD Tang, TT Ji, JR Dong, H Feng, FQ Chen… - International journal of …, 2021 - mdpi.com
… and progression while also revealing potential therapeutic targets [76]. One effective CRS …
player in severe sepsis-associated cytokine storms and a potential therapeutic target [90,91]. …

The signal pathways and treatment of cytokine storm in COVID-19

L Yang, X Xie, Z Tu, J Fu, D Xu, Y Zhou - … and targeted therapy, 2021 - nature.com
… levels of pro-inflammatory cytokines are produced during the crosstalk between epithelial
cells and immune cells in COVID-19, which has linked the cytokine storm (CS) with the severe …

Transcription factor Nrf2 as a potential therapeutic target for prevention of cytokine storm in COVID-19 patients

RA Zinovkin, OA Grebenchikov - Biochemistry (Moscow), 2020 - Springer
Therapeutic efficacy of these Nrf2 inducers is unknown for the cytokine storm and ARDS.
Potentially, Nrf2 inducers can be used to prevent cytokine storm or during its manifestation in …

The cytokine storm of COVID-19: a spotlight on prevention and protection

L Pearce, SM Davidson, DM Yellon - … on Therapeutic Targets, 2020 - Taylor & Francis
… been suggested that a cytokine storm of hyper-inflammation is … therapies which target the
COVID-19 induced cytokine storm. … Virus-induced cytokine storm is associated with Secondary …

Controlling cytokine storm is vital in COVID-19

L Tang, Z Yin, Y Hu, H Mei - Frontiers in immunology, 2020 - frontiersin.org
… It has been determined that cytokine storm is a major cause of … cytokine storm has become
a key therapeutic target. Although specific mechanisms of the occurrences of cytokine storms