… to disease progression. This review summarizes existing evidence on the molecular drivers
of diabetic kidney disease … unaddressed as primary treatment targets and for which there is …

… the pathogenesis and underlying mechanisms of renal disease. Among these models, mice
… events and potential therapeutic targets and to identify specific biomarkers of disease. Mice …

… pathways and may not, therefore, be the ideal therapeutic target since inhibition of such a
down-stream general target would likely be too toxic as many normal functions would be …

… DKD have identified emerging therapeutic targets. We review here the various mechanisms
known to contribute to DKD progression and possible therapeutic targets shown to be …

… and their downstream products are emerging as promising therapeutic targets.16, 17, 18 The
… DKD, with a focus on new biomarkers and candidate therapies that target these pathways. …

… This review summarizes the novel therapeutic targets related with hyperglycemia, … in the
kidney can lead to novel therapeutic interventions to stop the progression of the disease. The …

… the exact mode of Smad4 in kidney disease remains unclear, the diverse roles for Smad4 in
renal fibrosis and inflammation suggest that Smad4 may not be a therapeutic target for CKD. …

… therapies based on recent preclinical and clinical evidence. We focus, in particular, on potential
antifibrotic approaches that target … associated with progressive kidney diseases.8, 9 We …

… of chronic kidney disease (CKD) is fibrosis, as kidneys are … Myofibroblasts therefore
represent a new therapeutic target … are a major new target for therapeutics in kidney disease. …

… , diabetic nephropathy, glomerular biology, and IgA nephropathy. Identification of miRNA …
therapeutic targets in kidney fibrosis and related diseases. A new class of RNA therapeutics, …