… genome, pathophysiology, theranostics, and autophagy mechanisms. We will assess the
multiorgan … Our paper will provide mechanistic clues and therapeutic targets for physicians and …

… Studies with loperamide for diarrhoea and fibre for constipation used radiopaque markers
to assess whole gut transit time. These studies suggest that overall effects of these therapies …

… to be assessed with a desired therapeutic agent to control the consequences of TBI. The
current review gives a brief outline of the pathophysiological … , and novel targets for therapy. …

… pathophysiology, before amyloid deposition and neurodegeneration become too widespread.
Biological indicators of pathophysiological … that hit pathophysiological targets using clinical …

… underlying pathophysiological … target populations and disease stages (eg asymptomatic
to prodromal to syndromal). New integrated concepts and models of disease pathophysiology, …

… However, the current anti-VEGF therapies have limitations because they target only
VEGF … Many future therapies target these other mediators. AGE = advanced glycation end-products…

… Finally, in situ studies performed on isolated arteries can be used to identify novel potential
therapeutic targets. The use of drugs directed against such targets requires clinical validation…

… to cellular targets. Here, we give an overview of the pathophysiology of TBI and the underlying
molecular mechanisms, followed by an update on novel therapeutic targets and agents. …

… The lung parenchymal pathology is associated with highly … therapeutic targets which
exacerbate the disease pathology. … is that the COVID-19 pathology might predominantly involve …

… Also, the PAR-2-gene-deficient mice and the potent and metabolically stable agonists
are shown to be useful tools for evaluating the potency of PAR-2 as a therapeutic target. …