[HTML][HTML] Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods

C Wu, Y Liu, Y Yang, P Zhang, W Zhong… - … Pharmaceutica Sinica B, 2020 - Elsevier
target were predicted. This study will provide new lead compounds and targets for further in
vitro and in vivo studies of SARS-CoV-2, … drug repositioning to treat SARS-CoV-2 infections. …

Potential therapeutic targets and promising drugs for combating SARSCoV2

H Zhou, Y Fang, T Xu, WJ Ni, AZ Shen… - British Journal of …, 2020 - Wiley Online Library
… Therefore, accelerating research for potential therapeutic target confirmation… SARS-CoV-2.
Based on the current studies, we summarize the potential therapeutic targets involved in virus

[HTML][HTML] Role of structural and non-structural proteins and therapeutic targets of SARS-CoV-2 for COVID-19

R Yadav, JK Chaudhary, N Jain, PK Chaudhary… - Cells, 2021 - mdpi.com
SARS-CoV-2 is a new strain of corona virus that has not been traced in humans previously.
In this review, we primarily focus on multiple features of SARS-CoV-2… molecular targets, …

[HTML][HTML] SARS-CoV-2 pathophysiology and assessment of coronaviruses in CNS diseases with a focus on therapeutic targets

J Vallamkondu, A John, WY Wani, SP Ramadevi… - … et Biophysica Acta (BBA …, 2020 - Elsevier
… failure reported in advanced stages of SARS-CoV-2 infection. Our paper will provide
mechanistic clues and therapeutic targets for physicians and investigators to combat COVID-19. …

Proteomics of SARS-CoV-2-infected host cells reveals therapy targets

D Bojkova, K Klann, B Koch, M Widera, D Krause… - Nature, 2020 - nature.com
… Our results reveal the cellular infection profile of SARS-CoV-2SARS-CoV-2. Furthermore,
our findings provide insights for the development of therapies for the treatment of COVID-19. …

Potential therapeutic targets and vaccine development for SARS-CoV-2/COVID-19 pandemic management: a review on the recent update

U Anand, S Jakhmola, O Indari, HC Jha… - Frontiers in …, 2021 - frontiersin.org
therapeutic strategies; including vaccines and … of SARS-CoV-2 infection with the hope that
this integrative analysis could help develop novel therapeutic approaches against COVID-19. …

Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target

H Zhang, JM Penninger, Y Li, N Zhong… - Intensive care medicine, 2020 - Springer
… levels of its proteolytic target peptide angiotensin II, with a trend … SARS-CoV pathogenesis
makes ACE2 a rational and scientifically validated therapeutic target for the current COVID-19

Potential therapeutic targets for combating SARS-CoV-2: Drug repurposing, clinical trials and recent advancements

A Pandey, AN Nikam, AB Shreya, SP Mutalik… - Life sciences, 2020 - Elsevier
… Viral replication and transcription of SARS CoV-2 is carried out by complex protein … Overall
architecture of RdRp complex of SARS-CoV-2 is found to be analogous to that of SARS CoV. …

Structures of SARS-CoV-2 RNA-binding proteins and therapeutic targets

MT Khan, M Irfan, H Ahsan, A Ahmed, AC Kaushik… - Intervirology, 2021 - karger.com
… the identification of potential drug targets. These structures in… of many potential alternative
therapeutic targets, primarily in… drug target for effective control of current SARSCoV-2 pandemic…

Potential drug targets of SARS-CoV-2: From genomics to therapeutics

A Shamsi, T Mohammad, S Anwar, S Amani… - International Journal of …, 2021 - Elsevier
… The four major structural proteins of SARS-CoV-2 are the spike … 2 transmembrane protease
and thus plays a key role in virus … of SARS-CoV-2 to search for possible therapeutic options. …