The cytokine storm of severe influenza and development of immunomodulatory therapy

Q Liu, Y Zhou, Z Yang - Cellular & molecular immunology, 2016 - nature.com
… that cytokine storm … a cytokine storm remains limited. In this review, we focus on the potential
mechanisms responsible for severe influenza-induced cytokine storm and the therapeutic

Tocilizumab: a therapeutic option for the treatment of cytokine storm syndrome in COVID-19

A Saha, AR Sharma, M Bhattacharya, G Sharma… - Archives of medical …, 2020 - Elsevier
… that, the signaling of IL-6 plays an important role in inducing this cytokine storm (both by
its classical and trans signaling pathway) in seriously affected COVID patients and in order to …

Cytokine drizzle—the rationale for abandoning “cytokine storm

AE Stolarski, J Kim, Q Zhang, DG Remick - Shock, 2021 - journals.lww.com
… or drizzle may not be appropriate since this fails to identify which patients respond to therapy
We propose eliminating the term “cytokine storm” as there is no clear threshold of cytokine

[HTML][HTML] Cytokine storm intervention in the early stages of COVID-19 pneumonia

X Sun, T Wang, D Cai, Z Hu, H Liao, L Zhi, H Wei… - Cytokine & growth factor …, 2020 - Elsevier
… In the treatment of patients with SARS-CoV-2 infection, clinicians should pay close attention
… , and several effective cytokine storm blockers and therapeutic methods have been reported. …

Cytokine storm syndrome in coronavirus disease 2019: A narrative review

YM Gao, G Xu, B Wang, BC Liu - Journal of internal medicine, 2021 - Wiley Online Library
cytokines in patients with COVID-19, suggesting the existence of cytokine storm in some
critical illness patients. … In addition, a positive therapeutic effect was also seen in septic patients

[HTML][HTML] The signal pathways and treatment of cytokine storm in COVID-19

L Yang, X Xie, Z Tu, J Fu, D Xu, Y Zhou - … and targeted therapy, 2021 - nature.com
… levels of pro-inflammatory cytokines are produced during the crosstalk between epithelial
cells and immune cells in COVID-19, which has linked the cytokine storm (CS) with the severe …

Brain dysfunction in COVID‐19 and CAR‐T therapy: cytokine storm‐associated encephalopathy

U Pensato, L Muccioli, I Cani, D Janigro… - Annals of Clinical …, 2021 - Wiley Online Library
… The condition encompasses a broad spectrum of severity, 1 associated in a subgroup of
patients with cytokine storm, an acute systemic inflammatory syndrome that may lead to …

Pathogenesis and treatment of cytokine storm in COVID-19

M Soy, G Keser, MP Atagündüz - Turkish Journal of Biology, 2021 - journals.tubitak.gov.tr
… The question of whether immunomodulatory therapies improved survival in patients with
COVID-19 cytokine storm was also investigated by Narain et al., on behalf of the Northwell …

[HTML][HTML] Cytokine storm in COVID-19: the current evidence and treatment strategies

Y Tang, J Liu, D Zhang, Z Xu, J Ji, C Wen - Frontiers in immunology, 2020 - frontiersin.org
… (CAR)-T-cell therapy could help to distinguish CRS from a cytokine storm (2). Of note, the …
cytokine storm. In this review, we referred COVID-19 associated cytokine storm as the patients

[HTML][HTML] Pathogenesis and treatment of cytokine storm induced by infectious diseases

XD Tang, TT Ji, JR Dong, H Feng, FQ Chen… - International journal of …, 2021 - mdpi.com
… underlying cytokine storm induction … cytokine storms are described from both host and
pathogen perspectives. In summary, current studies indicate that cytokine storm-targeted therapies