… thymocytes is a developmental process in which TCR ligation with low avidity induces generation
of mature T cells. In mouse thymocytes, … involved in the selection of human thymocytes. …

… Immature T cells were obtained by eliminating mouse thymocytes that expressed the Lyt2 …
phorbol 12-myristate 13-acetate (PMA). We found that these "double-negative" thymocytes …

… C activation (by phorbol esters) and increased cytosolic free calcium (using calcium
ionophores) on the transcription of y-TCR genes in human thymocytes. These studies provide the …

… Recently, we showed that TPA induced DNA fragmentation of mouse thymocytes … or phorbol
esters induce the cleavage of nuclear DNA at linker regions in mouse immature thymocytes …

… Our results show that the combination of phorbol ester, a protein … thymus cultures, bypassing
TCR-induced positive selection signals. We found that the concentrations of phorbol ester …

… Because mitogen responsiveness is a property of mature medullary thymocytes and both
IL 1 and TPA can induce thymocyte maturation differentiation (9, 11, 26), we investigated …

… on developing thymocytes [10–13]. In keeping with these findings, ex vivo experiments with
human thymocytes previously reported by our group, revealed that while phorbol esters can …

At nanomolar concentrations, phorbol ester, a class of potent … Examination of phorbol and
other phrobol esters indicated … phorbol 12,13,-dibenzoate induced E + cells, while phorbol and …

… In experimental systems, recently it was shown that phorbol esters … In addition, phorbol esters
have been found to be directly … whether 12-0tetradecanoyl-phorbol-13 acetate (TP A) could …

… the large population of post-mitotic small lymphocytes in the thymus gland in vivo (Metcalf.
’66; … of the mitotic sequence as rapidly as in the thymus gland of the colcnicine (or colcemide)-…