Review on therapeutic targets for COVID-19: insights from cytokine storm

ML de Mélo Silva Júnior, LMA de Souza… - Postgraduate …, 2021 - academic.oup.com
cytokines (notably IL-1, IL-6 and TNF) and induce tissue damage and cell death, which leads
to a vicious cycle of inflammation (cytokine storm) and tissue … entry or to cytokine storm) and …

Autoinflammatory diseases and cytokine storms—imbalances of innate and adaptative immunity

A Marcuzzi, E Melloni, G Zauli, A Romani… - International Journal of …, 2021 - mdpi.com
… patterns associated with both pathogens and tissue damage. The different mutations of …
inflammatory cytokine, which plays a fundamental role both in innate immunity and inflammatory

Transcription factor Nrf2 as a potential therapeutic target for prevention of cytokine storm in COVID-19 patients

RA Zinovkin, OA Grebenchikov - Biochemistry (Moscow), 2020 - Springer
… the many inflammatory cytokines. Thus, it is extremely important to develop new approaches
to prevent cytokine storm during … All these factors contribute to cell and tissue damage [13]. …

Preliminary predictive criteria for COVID-19 cytokine storm

R Caricchio, M Gallucci, C Dass, X Zhang… - Annals of the …, 2021 - ard.bmj.com
… hyperimmune response characterised by a cytokine storm (CS).2 … diffuse inflammation and
widespread tissue damage, such … but also markers of inflammation and tissue damage. The …

Cytokine drizzle—the rationale for abandoning “cytokine storm

AE Stolarski, J Kim, Q Zhang, DG Remick - Shock, 2021 - journals.lww.com
… a “cytokine storm” resulting in an unregulated inflammatory … of blood cytokines necessary
to qualify as a “cytokine storm” … necessarily correlate with local tissue levels which may be …

[HTML][HTML] Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes

R Karki, BR Sharma, S Tuladhar, EP Williams… - Cell, 2021 - cell.com
… One possible mechanism linking cytokine storm to organ damage is the process of cell death.
Among the programmed cell death pathways, pyroptosis, apoptosis, and necroptosis have …

[HTML][HTML] Cytokine storm in COVID-19: from viral infection to immune responses, diagnosis and therapy

Y Jiang, L Rubin, T Peng, L Liu, X Xing… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
… Therefore, suppression of the cytokine storm is critical for … the mechanism of cytokine storm
and tissue damage induced … to the inflammatory response and cytokine storm, therefore …

Specific cytokines in the inflammatory cytokine storm of patients with COVID-19-associated acute respiratory distress syndrome and extrapulmonary multiple-organ …

J Wang, X Yang, Y Li, J Huang, J Jiang, N Su - Virology journal, 2021 - Springer
… the levels of inflammatory cytokines in … inflammatory cytokines with clinical and laboratory
variables were analyzed, furthermore, we also explored the relationships of different cytokines

Weathering the storm: harnessing the resolution of inflammation to limit COVID-19 pathogenesis

E Silberberg, JG Filep, A Ariel - Frontiers in Immunology, 2022 - frontiersin.org
… The former subset is recruited to inflamed tissues and the latter to non-inflamed tissues in a
… likely amplifies the pro-inflammatory cytokine cascade, resulting in a cytokine storm (133). A …

Intragastric and atomized administration of canagliflozin inhibit inflammatory cytokine storm in lipopolysaccharide-treated sepsis in mice: A potential COVID-19 …

Y Niu, Y Chen, P Sun, Y Wang, J Luo, Y Ding… - International …, 2021 - Elsevier
… played an important role in the pathological changes after LPS stimulation, we systematically
evaluated the effects of CAN on 18 inflammatory factor levels in lung tissues of LPS-…