Tissue remodelling in chronic bronchial diseases: from the epithelial to mesenchymal phenotype

M Pain, O Bermudez, P Lacoste… - European …, 2014 - Eur Respiratory Soc
… contribute to the remodelling of the airways. This phenomenon consists of the loss of the …
phenotype by bronchial epithelial cells and the acquisition of a mesenchymal phenotype. These …

Pathological relevance of epithelial and mesenchymal phenotype plasticity

M Guarino, P Micheli, F Pallotti, F Giordano - Pathology-Research and …, 1999 - Elsevier
mesenchyme and from mesenchyme to epithelium normally occur, allowing morphogenetic
processes and tissue remodelling … epithelial and the mesenchymal phenotypes is not limited …

Vascular remodelling and mesenchymal transition in systemic sclerosis

PA Nicolosi, E Tombetti, N Maugeri… - Stem Cells …, 2016 - Wiley Online Library
… development of a migratory phenotype. The retained plasticity … exhibit a phenotype normally
associated with tissue repair, … in vivo model to study the SSc phenotype in various cell types […

Epithelial to mesenchymal transition (EMT) and airway remodelling after human lung transplantation

LA Borthwick, SM Parker, KA Brougham, GE Johnson… - Thorax, 2009 - thorax.bmj.com
… and mesenchymal markers was compared in airway tissue … an epithelial to a mesenchymal
phenotype requires analysis of … is one functional characteristic of mesenchymal cells. The …

Epithelial-mesenchymal transition (EMT): the type-2 EMT in wound healing, tissue regeneration and organ fibrosis

GD Marconi, L Fonticoli, TS Rajan, SD Pierdomenico… - Cells, 2021 - mdpi.com
… cell proliferation and finally tissue remodeling. EMT is classified … acquire a mesenchymal
phenotype and express mesenchymalmesenchymal markers have already been obtained [12]. …

Pathological airway remodelling in inflammation

G Westergren‐Thorsson, K Larsen… - The clinical …, 2010 - Wiley Online Library
phenotypes and potential origins of these cells in airway … acquire a myofibroblast phenotype
in fibrotic tissue from patients with … In summary, it is clear that the airway mesenchymal cell …

Epithelial–mesenchymal transition, a spectrum of states: role in lung development, homeostasis, and disease

MK Jolly, C Ward, MS Eapen, S Myers… - Developmental …, 2018 - Wiley Online Library
… endobronchial biopsies and resected small airway tissue for vessel markers. We found large
… E/M phenotype as compared to the cells locked in a fully mesenchymal state. Consistently, …

Concepts of extracellular matrix remodelling in tumour progression and metastasis

J Winkler, A Abisoye-Ogunniyan, KJ Metcalf… - Nature …, 2020 - nature.com
… concepts of ECM remodelling shaping tissues for tumour cells … Myofibroblasts have a combined
phenotypic characteristic of … junctions, and downregulation of mesenchymal-specific and …

Senescent mesenchymal stem cells remodel extracellular matrix driving breast cancer cells to a more-invasive phenotype

D Ghosh, C Mejia Pena, N Quach… - Journal of cell …, 2020 - journals.biologists.com
… and connective tissues and differentiate into … remodeling diminished this invasive BCC
phenotype. These findings demonstrate the critical role senescence-induced matrix remodeling

Epithelial-mesenchymal transition in tissue repair and fibrosis

RC Stone, I Pastar, N Ojeh, V Chen, S Liu… - Cell and tissue …, 2016 - Springer
… plays a role in granulation tissue formation, epithelialization, and tissue remodeling (Powers
et al. … Increased production of type I collagen and mesenchymal phenotypic markers and …