Idiopathic pulmonary fibrosis (IPF) is a serious disease of the … the creation of excessive
fibrosis via different mechanisms, … as an alternative cell and tissue normal regeneration, which …

… Idiopathic pulmonary fibrosis (IPF) is a progressive chronic … in pulmonary hypertension
and idiopathic pulmonary fibrosis. … Therapeutic targets in lung tissue remodelling and fibrosis. …

… chronic inflammation was the underlying cause of pulmonary fibrosis.1, 2 This hypothesis …
of tissue inflammation correlate poorly to the severity or outcome of pulmonary fibrosis; and (2) …

… adult lung tissue to a fibrosis promoting ECM present in individuals with pulmonary fibrosis.
The … appearance of fibrotic remodeling often observed in both mouse models and human …

… may disrupt the normal tissue repair process that results in … tissue remodelling as summarised
in Figure 1. A number of different treatments have been used to elicit pulmonary fibrosis in …

… LOXL2 expression is relatively low in normal tissues so therapeutic targeting of this
enzyme … years of dysregulated remodelling, means that identifying patients before end-stage …

… In the lung, GAGs support the structure of the interstitium, the subepithelial tissue and the …
modulate inflammatory responses and influence lung tissue repair and remodelling [3]. Given …

… wall are critical for normal healing without fibrosis. The ability to rapidly accomplish this …
in progressive pulmonary fibrosis with aberrant bidirectional signaling between tissue …

… a significant role for these three growth and differentiation factors in the generation of the
chronic remodelling of the tissues seen in chronic inflammation including pulmonary fibrosis. …

Despite improvements in the diagnostic approach to idiopathic pulmonary fibrosis (IPF) in
recent years, the pathogenesis remains poorly understood. IPF is a clinical, physiologic, …