… TGF-β1 stimulates the contraction of myofibroblasts which may be important in tissue
remodelling and fibrocontractive responses [106]. TGF-β1 is also a strong chemoattractant for …

… Studies have proposed, so far, three different concepts related to the origin of IPF myofibroblast
foci: (1) Resident interstitial tissue lung fibroblasts stimulated by local pro-fibrotic growth …

… Ultimately, altered communication between aberrant epithelial and mesenchymal cells
leads to a loss of tissue homeostasis, culminating in tissue remodelling, contraction and …

… Pulmonary fibrosis is an irreversible accumulation of connective tissue in the interstitium of …
of lung regeneration and remodelling. This suggests that the pathogenesis of the progressive …

… Although mast cells are regarded as important regulators of inflammation and tissue
remodelling, their role in cystic fibrosis (CF) and idiopathic pulmonary fibrosis (IPF) has remained …

… and architectural disorganization-to those found in connective tissue disorders such as …
architectural disorganization of pulmonary parenchyma, hence the term remodelling, with …

… Pulmonary Fibrosis (IPF) lung tissue remodelling using immunohistochemical analysis. Methods
and results: 21 IPF and 19 control lung tissues … in the lung tissue remodelling capacity of …

… to spontaneous age-associated lung remodelling and fibrosis 72 . Telomere dysfunction
restricted … At the interface between fibrotic and normal-appearing lung tissue are aggregates of …

… for the development of pulmonary fibrosis. First, the … tissue disease-associated ILD. In
this context, an early phase of inflammatory pneumonitis is followed by a late phase of fibrosis. …

… Elimination of matrix-producing cells, clearance of collagen matrix and regeneration of normal
tissue are three important criteria necessary for fibrosis resolution [29]. Without these three …