… Healthy tissue is replaced by altered extracellular matrix and alveolar architecture is … , and
considerable extracellular matrix accumulation and remodelling of lung interstitium (figure 1). …

… and tissue repair, has been demonstrated in airway epithelial cells, lung fibroblasts and fibrotic
lung tissues.NGF … and in pulmonary fibrosis. Am J Resp Cell Mol Biol 1995; 13: 648−656. …

… for the treatment of patients with idiopathic pulmonary fibrosis. Our objective was to examine
the … connective tissue growth factor mRNA levels in the RV tissue. Connective tissue growth …

… are the main agents operating in the building and remodelling of fibrosis. Fibrosis may consist
of granulation tissue with loose connective matrix organisation (as in wound healing) or of …

… of airway or parenchymal fibrosis including asthma, idiopathic pulmonary fibrosis (IPF), …
mediators, namely TGF-β [87, 88] and IL-13 [89] are also highly expressed in fibrotic lung tissue …

… in different phases of ECM remodelling during repair and fibrosis. For example, decorin …
of patients with idiopathic pulmonary fibrosis (Clinicaltrials.gov identifier NCT01371305). …

… pathways mediating the IPF remodelling were found with a … consumption during lung
structural remodelling, which may … lung tissue from patients with idiopathic pulmonary fibrosis (…

… IPF [idiopathic PF (pulmonary fibrosis)] is a chronic and progressive interstitial lung disease
… TGF-β1, there is evidence of tissue remodelling, without any pronounced inflammation. …

… an important role in normal tissue repair processes. Tissue injury generally produces at least
… induces the expression of many genes that allow the tissue to adapt to hypoxia, to start the …

… to locations with ongoing tissue remodelling in IPF through … In pulmonary fibrosis patients,
fibroblast populations that are … a crucial role in the pathogenesis of fibrosis 104. Also after lung …