[HTML][HTML] TNF and its receptors in the CNS: The essential, the desirable and the deleterious effects

L Probert - Neuroscience, 2015 - Elsevier
… of TNF signaling in general, let alone in the CNS. In this review, evidence showing the effects
of TNF in … and molecular mechanisms that govern TNF function in general. Thus the roles of …

TNF-α and IFN-γ potentiate the deleterious effects of IL-1β on mouse pancreatic islets mainly via generation of nitric oxide

M Cetkovic-Cvrlje, DL Eizirik - Cytokine, 1994 - Elsevier
effects of cytokines on insulinproducing cells. In the present study we further characterized
the effects of IL-@, TNF-… The role of NO for the deleterious effects of combinations of cytokines …

Distinct and nonredundant in vivo functions of TNF produced by t cells and macrophages/neutrophils: protective and deleterious effects

SI Grivennikov, AV Tumanov, DJ Liepinsh, AA Kruglov… - Immunity, 2005 - cell.com
… Deregulated TNF production can be deleterious and has been clearly associated with
several autoimmune and inflammatory diseases, such as rheumatoid arthritis (RA) ( …

[PDF][PDF] The controversial role of tumor necrosis factor alpha in fibrotic diseases

JHW Distler, G Schett, S Gay, O Distler - Arthritis and rheumatism, 2008 - zora.uzh.ch
Tumor necrosis factor α (TNFα) is produced by a wide variety of hematopoietic and non…
stages of fibrosis might even show deleterious effects. Regarding safety issues, these trials need …

Deleterious role of TNF-α in retinal ischemia–reperfusion injury

S Berger, SI Savitz, S Nijhawan… - … & visual science, 2008 - iovs.arvojournals.org
TNF-α plays a largely deleterious role in ischemia–reperfusion … The diverse characteristics
of TNF-α are attributed in part to … the effects of the inhibition or activation of TNF-α on retinal …

Tumor necrosis factor α polymorphism correlates with deleterious effects of ultraviolet B light on cutaneous immunity

V Vincek, I Kurimoto, JP Medema, E Prieto, JW Streilein - Cancer research, 1993 - AACR
… injected tumor necrosis factor Âŧ(TNF-a) mimics the effects of … anli-TNF-Âŧ anti bodies abolish
the deleterious effects of I \ It … suggesting that TNF-n is the major mediator of UVB effects on …

TNF-α as a promising therapeutic target in chronic asthma: a lesson from rheumatoid arthritis

C Russo, R Polosa - Clinical science, 2005 - portlandpress.com
… Biological therapies blocking TNF-α are likely to … of TNF-α in asthma and to put forward
the idea that drugs that have been developed to neutralize the deleterious effects of TNF-α may …

Vitamin C abrogates the deleterious effects of UVB radiation on cutaneous immunity by a mechanism that does not depend on TNF-α

T Nakamura, SR Pinnell, D Darr, I Kurimoto… - Journal of investigative …, 1997 - Elsevier
… application of vitamin C can prevent the deleterious effects ofUVR … TNF-a-impaired Induction
ofCH -We have previously reported that TNF-a is a major mediator of the deleterious effects

N-Acetylcysteine Prevents the Deleterious Effect of Tumor Necrosis Factor-α on Calcium Transients and Contraction in Adult Rat Cardiomyocytes

M Cailleret, A Amadou, N Andrieu-Abadie, A Nawrocki… - Circulation, 2004 - Am Heart Assoc
… of NAC suppresses the deleterious effect of TNF-α on heart contraction. Importantly, NAC
also inhibits the nuclear factor-κB–dependent cardiac hypertrophic response to TNF-α. Taken …

The role of tumor necrosis factor alpha (TNF-α) in autoimmune disease and current TNF-α inhibitors in therapeutics

D Jang, AH Lee, HY Shin, HR Song, JH Park… - International journal of …, 2021 - mdpi.com
… has a higher affinity to TNF-α and can neutralize the biological activity of TNF-α effectively. …
are several side effects of TNF-α inhibitors. General side effects of all TNF-α inhibitors involve …