Salvianolic acid B inhibits atherosclerosis and TNF-α-induced inflammation by regulating NF-κB/NLRP3 signaling pathway

Y Zhao, C Shao, H Zhou, L Yu, Y Bao, Q Mao, J Yang… - Phytomedicine, 2023 - Elsevier
… The aim of this study was to investigate the protective effect of salvianolic acid B (Sal B)
on AS and to explore the molecular mechanism of tumor necrosis factor-α (TNF-α)-induced …

Salvianolic acid B from Salvia miltiorrhiza inhibits tumor necrosis factor-α (TNF-α)-induced MMP-2 upregulation in human aortic smooth muscle cells via suppression …

HS Zhang, SQ Wang - Journal of molecular and cellular cardiology, 2006 - Elsevier
… mechanisms underlying MMP-2 expression by salvianolic acid B in human aortic smooth
muscle cells. We demonstrated that salvianolic acid B inhibited TNF-α-induced MMP-2 activity …

Salvianolic acid B attenuates VCAM‐1 and ICAM‐1 expression in TNFα‐treated human aortic endothelial cells

YH Chen, SJ Lin, HH Ku, MS Shiao… - Journal of cellular …, 2001 - Wiley Online Library
… , salvianolic acid B (Sal B), … tumor necrosis factor-α (TNF-α)-treated human aortic endothelial
cells (HAECs) were investigated. When pretreated with SME (50 and 100 μg/ml), the TNF-α-…

The effect of salvianolic acid B combined with laminar shear stress on TNF-α-stimulated adhesion molecule expression in human aortic endothelial cells

LX Xie, SSK Durairajan, JH Lu, CL Liu… - Clinical …, 2010 - content.iospress.com
… the effect of Salvianolic acid B (Sal B) on TNF-α-stimulated … ) for 6 h decreased the TNF-α-induced
protein expression of … E-selectin expression stimulated by TNF-α. Moreover, combined …

Salvianolic Acid A Suppresses CCL-20 Expression in TNF-α–treated Macrophages and ApoE-deficient Mice

X Zhang, J Chen, B Li - Journal of cardiovascular pharmacology, 2014 - journals.lww.com
… to investigate the influence of salvianolic acid A (SAA) on the … TNF-α–induced CCL-20
production compared with TNF-α … the inhibitory effect of SB203580 on TNF-α–induced CCL-20 …

Salvianolic acid B attenuates plasminogen activator inhibitor type 1 production in TNFα treated human umbilical vein endothelial cells

Z Zhou, Y Liu, AD Miao… - Journal of Cellular …, 2005 - Wiley Online Library
… as tumor necrosis factor (TNF-α). In the present study, we investigated the effects of a potent
water-soluble antioxidant, salvianolic acid B (… of PAI-1 in TNF-α-treated human umbilical vein …

Salvianolic acid A attenuates kidney injury and inflammation by inhibiting NF-κB and p38 MAPK signaling pathways in 5/6 nephrectomized rats

H Zhang, Y Wang, C Gao, Y Gu, J Huang… - Acta Pharmacologica …, 2018 - nature.com
Salvianolic acid A (SAA) is a minor phenolic carboxylic acid extracted from Salviae
miltiorrhizae Bunge (Danshen). SAA exhibits a variety of pharmacological activities, such as …

Salvianolic acid B inhibits the TLR4-NFκB-TNFα pathway and attenuates neonatal rat cardiomyocyte injury induced by lipopolysaccharide

J Wang, Y Zhang, L Guo, G Wu, R Liu - Chinese journal of integrative …, 2011 - Springer
… The concentrations of tumor necrosis factor α (TNFα) and heat shock protein 70 (HSP70)
in the supernatant were detected by enzyme linked immunosorbent assay. The protein …

Salvianolic acids: small compounds with multiple mechanisms for cardiovascular protection

JHC Ho, CY Hong - Journal of biomedical science, 2011 - Springer
… LPS, but also inhibited MMP-2 activation induced by TNF-α, angiotension II and H 2 O 2 . It
has been demonstrated that Sal B inhibited TNF-α, angiotension II and H 2 O 2 -induced MMP…

Salvianolic acid B down-regulates matrix metalloproteinase-9 activity and expression in tumor necrosis factor-α-induced human coronary artery endothelial cells

L Ma, YQ Guan, ZD Du - Chinese Medical Journal, 2015 - journals.lww.com
… : Tumor necrosis factor-α. Effects of salvianolic acid B on tumor necrosis factor-α-stimulated …
were treated with 100 ng/ml TNF-α in the indicated time periods in order to detect if TNF-…