[HTML][HTML] Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes

R Karki, BR Sharma, S Tuladhar, EP Williams… - Cell, 2021 - cell.com
… cells during SARS-CoV-2 infection, we found that only the combination of TNF-α and IFN-γ …
Mechanistically, TNF-α and IFN-γ co-treatment activated the JAK/STAT1/IRF1 axis, inducing …

Roles of TNF-α gene polymorphisms in the occurrence and progress of SARS-Cov infection: A case-control study

S Wang, M Wei, Y Han, K Zhang, L He, Z Yang… - BMC Infectious …, 2008 - Springer
… of TNF-α polymorphisms in promoter region with SARS-Cov infection. Also, TNF-α gene
polymorphisms may no affect the occurrence of interstitial lung fibrosis in cured SARS patients. …

Up-regulation of IL-6 and TNF-α induced by SARS-coronavirus spike protein in murine macrophages via NF-κB pathway

W Wang, L Ye, L Ye, B Li, B Gao, Y Zeng, L Kong… - Virus research, 2007 - Elsevier
… The mechanism of SARS-CoV infection inducing the release of cytokines remains obscure.
… .7 with truncated SARS-CoV S protein led to production of IL-6 and TNF-α which were …

Pro-inflammatory CXCL-10, TNF-α, IL-1β, and IL-6: biomarkers of SARS-CoV-2 infection

AS Tripathy, S Vishwakarma, D Trimbake, YK Gurav… - Archives of …, 2021 - Springer
TNF-α (pg/mL) in SARS-CoV-2-infected patients with their concentrations in healthy controls
reveals the inefficiency of TNF-α … -10 (pg/mL) in SARS-CoV-2-infected patients with their …

Modulation of TNF-α-converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-α production and facilitates viral entry

S Haga, N Yamamoto… - Proceedings of the …, 2008 - National Acad Sciences
… We found that the spike protein of SARS-CoV (SARS-S) induced TNF-α-converting enzyme
(… and TNF-α production induced by SARS-CoV, we investigated the functions of HNL63-CoV. …

SARS-CoV-2: a storm is raging

SF Pedersen, YC Ho - The Journal of clinical investigation, 2020 - Am Soc Clin Investig
… -2–infected individuals, interleukin 6 (IL-6), IL-10, and tumor necrosis factor α (TNF-α)
surge during illness and decline during recovery. Patients requiring ICU admission have …

SARS-CoV-2 infection: The role of cytokines in COVID-19 disease

VJ Costela-Ruiz, R Illescas-Montes… - Cytokine & growth factor …, 2020 - Elsevier
… also been found to reduce the viral load of SARS-CoV-2 [26]. … capacity to suppress tumor
necrosis factor α (TNF-α) and interleukin… by blocking IL-6 and TNF-α or eliminating cytokines via …

Anti-TNF-α agents modulate SARS-CoV-2 receptors and increase the risk of infection through Notch-1 signaling

E Keewan, S Beg, SA Naser - Frontiers in Immunology, 2021 - frontiersin.org
coronavirus disease-2019 (COVID-19) pandemic. In this study, we investigated the effect
of anti-TNF-α … of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and …

SARS-CoV-2 accessory protein ORF7b mediates tumor necrosis factor-α-induced apoptosis in cells

R Yang, Q Zhao, J Rao, F Zeng, S Yuan, M Ji… - Frontiers in …, 2021 - frontiersin.org
… that an accessory protein ORF7b of SARS-CoV-2 induces TNF-α/IL6/IFN-β … a TNF signaling
pathway (Figure 5). These findings aid in understanding of the pathogenicity of SARS-CoV-2 …

… polymorphisms of ACE1, ACE2, IFTM3, TMPRSS2 and TNFα genes associated with susceptibility and severity of SARS-CoV-2 infection: A systematic review and …

V Pecoraro, M Cuccorese, T Trenti - Clinical and Experimental Medicine, 2023 - Springer
… Selected genes included ACE1, ACE2, IFITM3, TMPRSS2 and TNFα based on their involvement
in SARS-CoV-2 tropism to the human cells. Several studies have found that SARS-CoV-…