Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion

MR Young, JJ Li, M RINCon… - Proceedings of the …, 1999 - National Acad Sciences
… cells of the epidermis in transgenic mice. We report here that dominant negative c-jun-expressing
transgenic mice are inhibited for tumor promoter-induced AP-1 transactivation and are …

AP-1 in mouse development and tumorigenesis

W Jochum, E Passegué, EF Wagner - Oncogene, 2001 - nature.com
… of these knock-out mice, as well as studies in transgenic mice expressing individual … The
analysis of AP-1 components in transgenic mice and cells has identified specific functions in …

Alteration of intrahepatic cytokine expression and AP-1 activation in transgenic mice expressing hepatitis C virus core protein

T Tsutsumi, T Suzuki, K Moriya, H Yotsuyanagi… - Virology, 2002 - Elsevier
… -transgenic mice in the absence of inflammation in the liver. In these mice, the activation of
JNK and transcription factor AP-1… activates AP-1 in vivo, contributing to hepatocarcinogenesis. …

Inhibition of ultraviolet B-induced activator protein-1 (AP-1) activity by aspirin in AP-1-luciferase transgenic mice

C Huang, WY Ma, D Hanenberger, MP Cleary… - Journal of Biological …, 1997 - ASBMB
… of AP-1-luciferase transgenic mice, UVB irradiation induced a rapid increase in AP-1 activity,
which reached the peak at 48 h post-UVB irradiation. The topical pretreatment of mouse

Organ-specific distribution of AP-1 in AP-1 luciferase transgenic mice during the maturation process

SP Zhong, WY Ma, JA Quealy… - American Journal of …, 2001 - journals.physiology.org
… of AP-1 levels with maturation. In the present study, we used the AP-1-luciferase transgenic
mouse model to investigate AP-1 … upstream kinases that mediate AP-1 transcriptional activity. …

Functions of AP1 (Fos/Jun) in bone development

EF Wagner - Annals of the rheumatic diseases, 2002 - ard.bmj.com
… Moreover, the lethality of Fra-1 deficient mice was fully rescued by the ectopic expression
of Fra-1 from transgenic mice 14 demonstrating that AP1/Fra-1 activity during development …

The AP-1 transcription factor Batf controls TH17 differentiation

BU Schraml, K Hildner, W Ise, WL Lee, WAE Smith… - Nature, 2009 - nature.com
… Although Batf-transgenic mice had altered natural killer T cell development 21 , Batf -/- mice
had … We generated transgenic mice expressing Flag-tagged Batf under the control of the Cd2 …

AP-1 function and regulation

M Karin, Z Liu, E Zandi - Current opinion in cell biology, 1997 - Elsevier
… site, the AP-l-binding site. As the complexity of our knowledge of AP-1 factors has increased,
… of gene-knockout mice and cell lines deficient in specific AP-1 components. Such studies …

Regulation of GATA-4 and AP-1 in transgenic mice overexpressing cardiac calsequestrin

YJ Suzuki, T Ikeda, SS Shi, K Kitta, YM Kobayashi… - Cell Calcium, 1999 - Elsevier
1 CSQ overexpression upregulates DNA-binding … transgenic mouse hearts. Ventricular
homogenates (40 µg protein) from non-transgenic (NT) and CSQoverexpressing transgenic mice

AP1 transcriptional activity requires both T‐cell receptor‐mediated and co‐stimulatory signals in primary T lymphocytes.

M Rincon, RA Flavell - The EMBO journal, 1994 - embopress.org
… Based on these two observations, we believe that the reporter in these AP-1 transgenic
mice responds to appropriate signals and exhibits the appropriate response. In accord with the …