… mice with one of the earliest known isolates of SARS-CoV-2, our mouse model of SARS-CoV-2 …
caused by SARS-CoV-2 8 . Moreover, we also observed specific antibodies against …

… SARS-CoV-2 infection model using these transgenic mice. In our results, the infected mice
had two … Significant weight loss was only observed in dead and severely diseased mice. Thus, …

… Replication of SARS-CoV-2 to high titers in multiple organs likely reflects the expression
of hACE2 in cells of these organs in this transgenic mouse model [Citation20]. …

… caused by SARS-CoV in transgenic mice correlated with the … transgenic mouse has been
explored to mimic SARS-CoV-2 … with such transgenic mouse model, our hACE2 mouse model …

… for the study of SARS-CoV pathogenesis and cause lethal … -transgenic mice as a model for
severe COVID-19 disease. After intranasal SARS-CoV-2 inoculation, K18-hACE2 mice rapidly …

… course of SARS-CoV-2 infection in K18-hACE2 transgenic mice. … mice, which observed
successful infection with SARS-CoV-2 and a milder disease severity compared with SARS-CoV-1…

… model, which is susceptible to SARS-CoV-2 (30). In our pilot study, hACE2 transgenic
mice were intranasally inoculated with SARS-CoV-2 [2 × 10 6 TCID 50 (50% tissue culture …

… , SARS-CoV-2 lethality in K18 hACE2 transgenic mice has … K18 hACE2 transgenic mice
with SARS-CoV-2 to assess the … of SARS-CoV-2 infection and associated COVID-19 disease. …

… SARS-CoV-2 constructs with a validated rodent model of infection and disease. We
demonstrate that SARS-CoV-2 … disease outcome in K18 hACE2 transgenic mice, while ORF7a, …

… transgenic mouse model 21 supports efficient SARS-CoV-2 replication and pathogenesis
in vivo. Thus, this transgenic mouse … that uses wild-type SARS-CoV-2 and is appropriate for …