… We used the K18-hACE2 transgenic mouse model 22 to determine the protective efficacy of
two … Vaccine efficacy was tested against the ancestral SARS-CoV-2 B-lineage strain BavPat1 …

… (alveolar type II) cells. In this study, we generated an inducible transgenic mouse model that
… be invaluable to model COVID-19-related pathologies and their underlying mechanisms. …

… mouse ACE2 (refs. ), we observed less infection by B.1.1.529 in 129, C57BL/6, BALB/c and
K18-hACE2 transgenic mice than by previous SARS-CoV-2 … and hACE2 transgenic hamsters…

… to severe COVID-19. At the time of writing, in vivo studies of SARS-CoV-2 infection have
been described using macaques, cats, ferrets, hamsters, and transgenic mice expressing …

… [45] used the hACE2 transgenic mice and infected them with SARS-CoV-2 inducing interstitial
pneumonia, with typical histopathological elements and, accordingly, viral antigens were …

… originally developed to study SARS-CoV pathogenesis and cause … transgenic mice as a
model for severe COVID-19 disease. After intranasal SARS-CoV-2 inoculation, K18-hACE2 mice …

… ) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), …
SARS-CoV-2 infection of K18-hACE2 transgenic mice. Eighty percent of the untreated mice …

… mice to aerosolized virus under controlled conditions. Aerosol exposure of K18-hACE2
transgenic mice to SARS-CoV-2 … tract of SARS-CoV-2–infected K18-hACE2 transgenic mice. We …

… While hACE2 transgenic mice support infection and pathogenesis, these … Here we report
the development of a mouse model of SARS-CoV-2 based on adeno-associated virus (AAV)–…

… infection in a virus dose-dependent manner. The relationship between SARS-CoV-2 and …
lung microbiomes of SARS-CoV-2-challenged K18-hACE2 transgenic mice in the presence or …