Coronavirus disease 2019: investigational therapies in the prevention and treatment of hyperinflammation

I Amigues, AH Pearlman, A Patel, P Reid… - Expert review of …, 2020 - Taylor & Francis
… Introduction: The mortality of coronavirus disease 2019 (COVID-19) is frequently driven by …
Coronavirus disease 2019 (COVID-19) pandemic is an ongoing threat to global health. COVID

High-dose intravenous vitamin C attenuates hyperinflammation in severe coronavirus disease 2019

G Xia, D Fan, Y He, Y Zhu, Q Zheng - Nutrition, 2021 - Elsevier
treating patients with coronavirus disease 2019 (COVID-19). The aim of this study was to
assess the clinical efficacy of HIVC on hyperinflammation in patients with severe COVID-19. …

The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The Perspectives of clinical immunologists from …

W Zhang, Y Zhao, F Zhang, Q Wang, T Li, Z Liu… - Clinical …, 2020 - Elsevier
… of coronavirus disease 2019 (COVID-19) is rapidly spreading all over the world. Reports from
China showed that about 20% of patients developed severe disease, … of critical COVID-19 …

A novel definition and treatment of hyperinflammation in COVID-19 based on purinergic signalling

D Hasan, A Shono, CK van Kalken, PJ van der Spek… - Purinergic …, 2022 - Springer
… P2X7R antagonist lidocaine can abrogate hyperinflammation and restore the normal immune
… ) local hyperinflammation. We illustrate this with six critically ill COVID-19 patients treated

[HTML][HTML] Hyperinflammation in two severe acute respiratory syndrome coronavirus 2-infected adolescents successfully treated with the interleukin-1 inhibitor anakinra …

FI Calò Carducci, MA De Ioris, C Agrati… - Frontiers in …, 2020 - frontiersin.org
… 41,570,883 confirmed cases and 1,134,940 coronavirus disease 2019 (COVID-19)-related
deaths worldwide (1). In critically ill adult patients, hyperinflammation is considered to play a …

[HTML][HTML] Immunopathology of Hyperinflammation in COVID-19

JN Gustine, D Jones - The American journal of pathology, 2021 - Elsevier
… Dexamethasone was also more effective in patients randomized to receive treatment for >7
versus ≤7 days after the onset of COVID-19 symptoms (P < 0.001). Dexamethasone was the …

Role for anti-cytokine therapies in severe coronavirus disease 2019

LF Buckley, GF Wohlford, C Ting… - Critical care …, 2020 - journals.lww.com
… In some patients, the resulting hyperinflammation resembles … of the immunopathogenesis
of coronavirus disease 2019 is … a treatment option for adults with severe coronavirus disease

[HTML][HTML] Hyper-inflammatory responses in COVID-19 and anti-inflammatory therapeutic approaches

H Choi, EC Shin - BMB reports, 2022 - ncbi.nlm.nih.gov
… modality for treating dysregulated inflammatory responses in COVID-19, … diseases have
indicated the possibility of applying exosomes in the treatment of hyper-inflammation in COVID-…

[HTML][HTML] Hyperinflammation with COVID-19: The key to patient deterioration?

K Haigh, ZJ Syrimi, S Irvine, TJ Blanchard… - Clinical infection in …, 2020 - Elsevier
… with coronavirus disease 2019 (COVID-19) has been described [1]; we write to share our
experience treating a 17… to the scientific community as a treatment option in COVID-19 infection. …

Hypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19

S Trump, S Lukassen, MS Anker, RL Chua… - Nature …, 2021 - nature.com
… insights into the differential COVID-19 pathology in patients treated with ACEI/ARB compared
to patients without cardiovascular diseases or with a different anti-hypertensive treatment. …