… the relevance of the mTOR pathway to epileptogenesis and its potential as a therapeutic
target in epilepsy treatment by presenting the most recent findings on mTOR inhibitors. …

… inhibitors with MEK inhibitors has already proved to be an efficacious treatment strategy for
… of the combination of the BRAF inhibitor, dabrafenib, with the MEK inhibitor, trametinib, in …

… of pathways inhibited by treatment and/or counteracting mechanisms of resistance. In
addition, as for classic cytotoxic agents, an intact BBB may represent an important impediment …

… inhibitors in melanoma as they are developed clinically. One strategy to achieve significant
pathway inhibition … use of isoform-specific PI3K inhibitors. Genetic studies in mouse models …

… inhibited by G12C-specific inhibitors. Our data suggest that vertical pathway inhibition
strategies, and in particular combinations of KRAS G12C inhibitors with SHP2 inhibitors—which …

… with other pathway inhibitors. It is increasingly clear that antitumor efficacy and response …
with inhibitors of a single kinase are frequently limited by parallel signaling, bypass pathway …

… for better approaches to inhibitor design. Here, we discuss alternative strategies that might
lead to better p38 inhibitors, including non-ATP-competitive inhibitors and inhibitors that are …

… for EGFR-mutant NSCLC treatment. In this article, we reviewed the benefit of VEGF pathway
inhibition in NSCLC, the preclinical evidence for dual EGFR-VEGF pathway inhibition, and …

… This review describes an expanded role for the PI3K pathway in … treatment strategies
combining PI3K pathway inhibitors with DDR blockades to improve the efficacy of these inhibitors …

… including PI3K, Akt and mTOR as well as other knots such as PDK for the treatment of … -molecule
kinase inhibitors of PI3K/Akt/mTOR transduction pathways for the treatment of cancer. …