Muscle wasting diseases: novel targets and treatments

R Furrer, C Handschin - Annual review of pharmacology and …, 2019 - annualreviews.org
… for muscle wasting, and muscle remains an under-medicated organ… muscle wasting and
summarizes novel experimental and clinical pharmacological avenues aimed at skeletal muscle

Molecular mechanisms and treatment options for muscle wasting diseases

MA Rüegg, DJ Glass - Annual review of pharmacology and …, 2011 - annualreviews.org
treatment of muscular dystrophies, in particular DMD, target the disease-causing dystrophin.
Muscle wasting is also a characteristic feature of muscle … that treatments preventing muscle

Cancer-induced muscle wasting: latest findings in prevention and treatment

Z Aversa, P Costelli… - Therapeutic advances in …, 2017 - journals.sagepub.com
… evidence suggests that further studies are needed before the ubiquitin proteasome system
may be definitely identified as a possible therapeutic target for muscle wasting in cancer. …

[HTML][HTML] Emerging therapies for the treatment of skeletal muscle wasting in chronic obstructive pulmonary disease

SL Passey, MJ Hansen, S Bozinovski… - Pharmacology & …, 2016 - Elsevier
… There are currently few therapeutic options to target oxidative stress in muscle wasting (Table
2), and the full effect of reducing the oxidant burden in COPD is not completely understood…

Muscle wasting in disease: molecular mechanisms and promising therapies

S Cohen, JA Nathan, AL Goldberg - Nature reviews Drug discovery, 2015 - nature.com
… intracellular targets for … muscle wasting in rats treated with dexamethasone, or during sepsis
induced by caecal ligation and puncture 118 . Therefore, treatment of acute muscle wasting

Therapeutic approaches for muscle wasting disorders

GS Lynch, JD Schertzer, JG Ryall - Pharmacology & therapeutics, 2007 - Elsevier
… Hormonal and/or other drug strategies that can target key steps in the molecular … maintain
muscle mass and provides an overview of some of the major conditions where muscle wasting

Drugs of muscle wasting and their therapeutic targets

K Sakuma, A Yamaguchi - Muscle Atrophy, 2018 - Springer
muscle wasting, although further systematic research is needed on this treatment in …
This chapter outlines several recent pharmacological approaches to inhibit muscle wasting. …

Muscle wasting in end-stage renal disease promulgates premature death: established, emerging and potential novel treatment strategies

P Stenvinkel, JJ Carrero, F Von Walden… - Nephrology Dialysis …, 2016 - academic.oup.com
… Here, we review a few potentially promising novel therapeutic targets (Table 1). The
possibility to treat muscle wasting by anti-inflammatory treatment strategies [7, 48] as well as …

Muscle wasting: emerging pathways and potential drug targets

A Domaniku, SN Bilgic, S Kir - Trends in Pharmacological Sciences, 2023 - cell.com
… Clinical trials testing therapeutics against muscle wasting have yielded limited success. …
patients, muscle wasting negatively influences survival by reducing tolerance of treatment and …

Treatment of muscle wasting: an overview of promising treatment targets

S von Haehling, J Springer - Journal of the American Medical Directors …, 2015 - jamda.com
treatment regimens to tackle muscle wasting and cachexia in patients with chronic diseases,
but also the muscle wasting … It is important to understand that muscle wasting is in many …