… Epitope repertoire in SARS-CoV-2–unexposed individuals To define the repertoire of CD4
+ T cells recognizing SARS-CoV-2 epitopes in previously unexposed individuals, we used in …

… SARS-CoV-2-reactive CD4 + T cells in ∼40%–60% of unexposed individuals, suggesting
cross-… T cell recognition between circulating "common cold" coronaviruses and SARS-CoV-2. …

… and Unexposed Donors To obtain a deeper insight into the cellular composition of SARSCoV-2-…
-activated cell sorting (FACS)-purified SARS-CoV2-reactive memory T cells. After quality …

… , SARS-CoV-2-cross-reactive T cells, which correlated with the strength of human seasonal
coronavirus … -resident SARS-CoV-2-reactive T cells in next-generation mucosal vaccines. …

… (phytohemagglutinin) for each individual. P2 was … unexposed HD who donated their
blood during the pandemic as controls, so we cannot exclude a potential infection by SARS-CoV-2 …

… mapped at epitope levels across the SARS-CoV-2 proteome (36)… in unexposed individuals
were cross-reactive to SARS-CoV-2 … (24) examined individuals who recovered from SARS 17 …

… The goal of the study was to define the preexisting state of SARS-CoV-2–specific T cells
in unexposed individuals. Cryopreserved cells were stored from past collection of de-identified …

… severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are more commonly
detected in the peripheral blood of unexposed individuals compared with SARS-CoV-2–reactive …

… These four MPs were tested in two different cohorts, unexposed … The unexposed cohort still
responded to the SARS-CoV-2 pool… SARS-CoV-2 and other HCoVs exist in many individuals. …

… both SARS-CoV-2 and Hepatitis C, T-cell responses in exposed seronegatives are consistently
higher than in unexposed individuals, … Finally, exposure to SARS-CoV-2 induces varying …