… to bind to SARS-CoV-2 S2 protein directly and block the prefusion state of spike protein. …
4.1.1. para-Methoxybenzyl-3β-hydroxy-urs-12-en-28-oic acid (1) To a solution of ursolic acid (…

… Structure–activity relationships of 3-O-β-chacotriosyl ursolic acid derivatives as novel H5N1
entry … In silico molecular docking analysis targeting SARS-CoV-2 spike protein and selected …

… mainly the oleanolic acid (-8.55 kcal/mol), the ursolic acid (-… of human heat shock protein
90 with seleno derivatives of … cleavage site inserted into the spike protein of SARS-CoV-2: A …

… at least three triterpene derivatives of each type (ie, oleanolic, moronic and ursolic) present
… acid. Molecular dynamics suggest that two compounds from oleanolic and ursolic acid, OA5 …

… STAT3), phosphatidylinositol 3 kinase/Akt (PI3K/Akt), nuclear factor kappa B (NF-κB), advanced
glycation end-products (AGEs) and its receptors (RAGE), high mobility group box protein …

… -2 Spike protein and that … ursolic acids have been proved to act as selective and potent
GPBAR1 agonists (Sato et al., 2007; Genet et al., 2010; Lo et al., 2016), while glycyrrhetinic acid, …

… interaction with the amino acid residues of the spike protein. ARG 493 amino acid residue
of spike protein was involved in hydrogen bonding with the Ursolic acid. Besides, ARG 403, …

… the nsp7 protein, and GA binds to the spike protein RBD of … with ursolic acid and betulinic
acid as the most potent ones. The IC 50 values for GA, GA-g, A3, betulinic acid, and ursolic acid …

… be involved in the activation of the viral spike protein (S-protein), which is considered a key
… Finally, we would like to highlight the activity of ursolic acid (UA) (42) that was found to have …

… As we all know, understanding how drugs and proteins interact plays an important role in …
Molecular docking is used to predict the binding modes of proteins and ligands [37]. MDS is an …