… type I IFN. In this study, we examined the antiviral potential of exogenous human IFN-λ1 in
cellular … For a more accurate assessment of the therapeutic potential of IFN-λ1, we carried out …

… binding of various interferon regulatory … level of expression of IFN-λ1 mRNA, followed by
IFN-λ2 mRNA, and a delayed and low level of IFN-β mRNA, with no significant change in levels …

… IL-28A/B and IL-29 (also known as IFN-λ2/3 and IFN-λ1, respectively), posses … IFN-α
sensitizes the cells to microbial stimulation by up-regulating the expression of TLRs and various …

… IFN-λ1 in autoimmune diseases including RA remains elusive. Here we studied IFN-λ1
expression levels … in RA IFN-λ1 was abnormally elevated and associated with knee joint disease. …

… , we determined whether IFN-λ induced the same level of cell growth inhibition relative to
IFN-α. … growth inhibited by IFN-α, underwent apoptosis in response to IFN-λ. Next, in contrast to …

… high levels of IFN-λ1 and IFN-α are associated with different clinical and serological profiles.
IFN-λ1 … Various impacts of IFN-λ and IFN-α subtypes could also explain contrasting clinical …

… IFN-λ1 and IFN-β gene expression largely depends on IRF3 and NF-κB. Expression of … In
this study, the response to circulating IFN-λ was evaluated in vivo in various mouse organs after …

… : IFN-λ1 [interleukin-29 (IL-29)], IFN-λ2 (IL-28A), and IFN-λ3 (… of two chains, an IFN-λ-specific
IFN-λR1 selectively expressed … the various NEMO mutations have different impacts on IFN-α/…

… by IFN-λ1 at the level of mRNA transcript levels (Figure 4). IFN-λ1 was able to upregulate basal
levels … over a period of 32 h with supernatants harvested at various time points during the …

… level, the response to IFN-λ in kidney and brain was restricted to epithelial cells. In contrast,
the response to IFN-α/β was observed in various … this new family: IFN-λ1, IFN-λ2 and IFN-λ3. …