Salvianolic acid B and its magnesium salt inhibit SARS-CoV-2 infection of Vero-E6 cells by blocking spike protein-mediated membrane fusion

C Yang, C Cheng, J Wang, K Chen, J Zhan… - … Fang yi ke da xue xue …, 2021 - europepmc.org
Objective The investigate the inhibitory effects of the traditional Chinese medicine (TCM)
monomer salvianolic acid B (Sal-B) and its magnesium salt Salvia Miltiorrhiza Polyphenolate …

Salvianolic acid C potently inhibits SARS-CoV-2 infection by blocking the formation of six-helix bundle core of spike protein

C Yang, X Pan, X Xu, C Cheng, Y Huang, L Li… - Signal transduction and …, 2020 - nature.com
… We determined EC50 of Sal-C against authentic SARS-CoV-2 on Vero-E6 cells with a full-time
treatment model. As shown in Fig. 1 d, Sal-C showed the potent antiviral activity with …

Anti-SARS-CoV-2 activities of tanshinone IIA, carnosic acid, rosmarinic acid, salvianolic acid, baicalein, and glycyrrhetinic acid between computational and in vitro …

D Elebeedy, WF Elkhatib, A Kandeil, A Ghanem… - RSC …, 2021 - pubs.rsc.org
… the superior affinities of both salvianolic acid B (4) and glycyrrhetinic acid (6) as the …
measuring their CC 50 values using MTT assay on Vero E6 cells. Surprisingly, tanshinone IIA (1) …

Danshensu alleviates pseudo-typed SARS-CoV-2 induced mouse acute lung inflammation

W Wang, S Li, X Xu, C Yang, X Niu, S Yin… - Acta Pharmacologica …, 2022 - nature.com
… Previous studies showed that Salvianolic acid B and sodium … Our previous results also
indicated that Salvianolic acid C has … After SARS-CoV-2 inhibition assay, Vero-E6 cells on 48 well …

[HTML][HTML] Natural triterpenoids from licorice potently inhibit SARS-CoV-2 infection

Y Yi, J Li, X Lai, M Zhang, Y Kuang, YO Bao… - Journal of advanced …, 2022 - Elsevier
… 10 µM at different steps of pseudovirus infection in Vero E6 cells, n ≥ 3. Luminescence was
… Cytotoxicities of the drugs against the Vero E6 cells were tested by CCK-8 assay. For each …

Salvia miltiorrhiza Bunge as a Potential Natural Compound against COVID-19

SJL Petitjean, M Lecocq, C Lelong, R Denis, S Defrère… - Cells, 2022 - mdpi.com
… hydrophilic phenolic compounds (such as salvianolic acids) are the major active compounds
… [Salvianolic acid B and its magnesium salt inhibit SARS-CoV-2 infection of Vero-E6 cells by …

SARS-CoV-2 Main Protease Inhibitors from Natural Product Repository as Therapeutic Candidates for the Treatment of Coronaviridae Infections

MA Khanfar, MI Saleh - Current Medicinal Chemistry, 2024 - ingentaconnect.com
… tory activity for salvianolic acid A with IC50 = 2.49 µM [55]. Interestingly, salvianolic acid A …
However, it displayed moderate inhibition against SARS-CoV-2 propagated in Vero E6 cells …

[HTML][HTML] Identification of natural compounds as SARS-CoV-2 entry inhibitors by molecular docking-based virtual screening with bio-layer interferometry

D Zhang, S Hamdoun, R Chen, L Yang, CK Ip… - Pharmacological …, 2021 - Elsevier
salvianolic acid A (SalA), and isoliensinine (Isl), were effective in inhibiting SARS-CoV-2-induced
cytopathic effect and plaque formation in Vero E6 … demonstrated that salvianolic acid A, …

Identification, optimization, and biological evaluation of 3-O-β-chacotriosyl ursolic acid derivatives as novel SARS-CoV-2 entry inhibitors by targeting the prefusion …

H Li, C Cheng, S Shi, Y Wu, Y Gao, Z Liu, M Liu… - European Journal of …, 2022 - Elsevier
… has previously reported that the natural polyphenol compound salvianolic acid C (Sal-C) from
… Then using infectious SARS-CoV-2 (wuhan-HU-1 variant) in Vero-E6 cells, we evaluated …

[PDF][PDF] Salvia miltiorrhiza Bunge as a Potential Natural Compound against COVID-19. Cells 2022, 11, 1311

SJL Petitjean, M Lecocq, C Lelong, R Denis, S Defrère… - 2022 - academia.edu
… hydrophilic phenolic compounds (such as salvianolic acids) are the major active compounds
… [Salvianolic acid B and its magnesium salt inhibit SARS-CoV-2 infection of Vero-E6 cells by …