… Murine norovirus (MNV), a recently discovered viral agent of laboratory mice, is closely
related to human norovirus, a … Because MNV is unique among norovirus strains in its ability to …

… cells with a cDNA clone of Norwalk virus (NV) or U201, both human noroviruses (2, 37). …
murine and human norovirus replication suggests that noroviruses, like some other RNA viruses, …

… noroviruses (HuNoVs) are the leading etiologic agent of viral … To determine whether HuNoV
adapted to its murine host, we … 9 [see Table S1 in the supplemental material]) (norovirus Hu/…

… The detection of murine norovirus in laboratory mice has raised concerns for its effect on …
natural exposure to the virus, most likely by the introduction of the virus from an outside source …

… are necessary for persistent viral infection. However, recent work in the murine norovirus (MNV) …
can control both early and persistent viral replication independently of adaptive immune …

… Because of these limitations in assessing human norovirus infectiv-ity, current methods …
based on viral surrogates. Surrogates for human noroviruses have included murine norovirus (…

… viruses (mouse hepatitis virus, pneumonia virus of mice, Sendai virus, Theiler murine
encephalomyelitis virus, … virus, ectromelia virus, mouse cytomegalovirus, minute virus of mice, …

… reported murine norovirus (MNV) as the most prevalent agent (… with MNV, the most common
viral agent, on MPV pathogenesis … Murine norovirus is a small nonenveloped RNA virus that …

… viruses that infect a range of mammals, including humans and mice. Murine noroviruses (…
extensively as a model system for human noroviruses (HuNoVs). Despite recent successes …

… Murine norovirus (MNV) is an enteric virus that, like its human counterparts, is spread by
the fecal-oral route (58). MNV-infected mice make a significant antibody response (17, 18, 23, …