[PDF][PDF] Is COVID-19 a cytokine storm driven viral sepsis?

R Gupta - Polymorphism, 2020 - researchgate.net
… with cytokine storm and hypercoagulation/viral load on higher side. On the contrary, only
anti-virals should be good for asymptomatic RT-PCR positive patients. However, more basic …

Targeting cytokine storm to manage patients with COVID-19: a mini-review

N Roshanravan, F Seif, A Ostadrahimi… - Archives of medical …, 2020 - Elsevier
… On the other hand, TLR activation following a viral infection can induce the production of IL-6
by monocytes and macrophages. TLRs, TNFα, and IL-1β are known as the main stimulators …

Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms

S Kang, T Kishimoto - Experimental & molecular medicine, 2021 - nature.com
… Thus, increased cytokine production controls some disseminated infections; however, …
HHV-8 encodes a homolog of human IL-6, referred to as viral IL-6 (vIL-6), which is produced by …

Novel coronavirus disease 2019 (COVID-19) and cytokine storms for more effective treatments from an inflammatory pathophysiology

S Yokota, T Miyamae, Y Kuroiwa… - Journal of Clinical …, 2021 - mdpi.com
… , progressing into disseminated intravascular coagulation disseminated intravascular …
Therefore, baricitinib could prevent both the invasion of viruses into the lung cells of patients …

Pathogenesis and treatment of cytokine storm in COVID-19

M Soy, G Keser, MP Atagündüz - Turkish Journal of Biology, 2021 - journals.tubitak.gov.tr
… A hyperinflammatory state resulting in a cytokine storm and adult respiratory distress …
cytokine storm (COVID-CS). Insufficient viral clearance and persistence of a strong cytokine

The role of IL-6 and other mediators in the cytokine storm associated with SARS-CoV-2 infection

A Copaescu, O Smibert, A Gibson, EJ Phillips… - Journal of Allergy and …, 2020 - Elsevier
… or leukopenia, thrombocytopenia, and disseminated intravascular coagulation with high …
the levels of this cytokine, a direct pathogenic mechanism of cellular viral entry involving the …

When does the cytokine storm begin in COVID-19 patients? A quick score to recognize it

S Cappanera, M Palumbo, SH Kwan, G Priante… - Journal of clinical …, 2021 - mdpi.com
… The CS syndrome led to MODS and disseminated intravascular coagulation (DIC) and most
… , and concluded that COVID-19 mortality may be due to a virus-related “cytokine storm”. Ref. …

The Nonstructural Protein NSs of Severe Fever with Thrombocytopenia Syndrome Virus Causes a Cytokine Storm through the Hyperactivation of NF-κB

J Khalil, S Yamada, Y Tsukamoto, H Abe… - … and Cellular Biology, 2021 - Taylor & Francis
… rate are the virus-induced cytokine storm, coagulopathy due to disseminated intravascular
coagulation, … The cytokine storm is an excessive inflammatory reaction characterized by the …

On the alert for cytokine storm: immunopathology in COVID‐19

LA Henderson, SW Canna, GS Schulert… - Arthritis & …, 2020 - Wiley Online Library
… from other forms of viral-induced cytokine storm, in that ferritin … the virus for the lung. However,
critically ill patients with COVID-19 often demonstrate features suggestive of cytokine storm

Cytokine storm induced by SARS-CoV-2 infection: The spectrum of its neurological manifestations

P Thepmankorn, J Bach, A Lasfar, X Zhao, S Souayah… - Cytokine, 2021 - Elsevier
… lungs, disseminated intravascular coagulation (DIC), and HLH [45]. … of viral load becomes
an obvious goal for treatment or prophylaxis. Targeting cytokine storm along with reducing viral