… cell constraints on virus replication. Here we demonstrate how cells, including MRC5 cells
(which are human diploid cells … the production of attenuated viruses for use in humans), can …

… (HCV) is unusual in that it does not study the natural virus, but instead studies are based on
… of viral RNA and proteins from patient sera or on replicating virus isolated from cells infected …

… positive-strand RNA virus replication complexes have parallels and … virus and retrovirus
virions and more general similarities with the replication factories of cytoplasmic DNA viruses. …

… virus. This chapter describes the details of what occurs during each stage of viral replication…
, scientists can infect cells with virus to observe the kinetics of the viral replication cycle. One-…

… of viral and cellular proteins as the viral replication cycle proceeds. … human cells and human
immunodeficiency virus 1 (HIV-1) illustrates the complexity of the interaction between virus …

… steps of the viral replication cycle but also to control the cellular mechanisms of … viral
replication compartments from different virus families and discuss similarities in the viral and cellular …

… Here, we show that the human proteins ANP32A and ANP32B are essential for influenza
A and B virus replication, such that in their absence cells become impervious to the virus. We …

… of virus cDNA of the so-called human FV isolate (HFV) in cells transfected with a virus mutant
deficient in the envelope gene and in cells … We show that the synthesis of viral cDNA is …

… To evaluate those factors that affect virus replication but not influenza virus entry, we
monitored the localization of the influenza virus nucleoprotein (NP) in siRNA-depleted cells after …

… Second, to more globally assess the potential of small regulatory RNAs to inhibit virus
replication, we used gene editing to derive human cell lines that lack a functional Dicer enzyme …