… By comparing viral infection in wild-type, IFNLR1 0/0 , IFNAR 0/0 and double-knockout mice…
contribution of IFN-λ to the control of viral infection greatly varied according to the virus [13]. …

… In order to evaluate the antiviral activity of IFN-λ in vivo, we … viral infection to test whether
IFN-λ or IFN-α treatment could protect the mice from viral infection: C57BL/6 mice were infected …

… Type-III interferons (IFN-λ, IFNL) are the most recently … biology of IFNL during viral infection,
and the implications of this … IFNLs exert antiviral effects via induction of IFN-stimulated genes…

… IFN-λ receptor IL10R2/IFNLR1 (Table 1) and their genes are clustered on human chromosome
19. Similarly to type I IFN, their inducibility by virus infection appears to be ubiquitous [6]. …

… This study describes the dynamics of IFN-β responses to viral infection using lung infection
… other IFN pathways such as IFN-λ could also be effective at modulating viral infections (36–39…

… to IFN-λ, whereas other cells of the gut mainly rely on IFN-α/β for antiviral defense. We suggest
that IFN-λ may have evolved as an autonomous virus … frequent triggering of the IFN-α/β …

… of and response to IFN-α/β during viral infections. The TLR3-UNC-93B-… viral infections.
This observation suggests that UNC-93B-dependent, virus-induced IFN-α, IFN-β, and IFN-λ …

… IFN receptor, we demonstrate that intranasal influenza A virus infection leads to the robust
type III IFN … from HK-X31 virus with IFN-λ expression, we measured IFN-λ protein levels in BAL …

… In contrast, the protective role of IFN-λ during viral infections of the small intestine was … IFN-λ
is more potent in containing viral infections within the upper respiratory tract than type I IFN. …

… to infection. Importantly, recombinant IFN-λ has therapeutic potential against enteric viral
infections… recent advances regarding IFN-λ-mediated regulation of enteric viruses with important …