… In this Review, we summarize the first discoveries that shape our current understanding
of SARS-CoV-2 infection throughout the intracellular viral life cycle and relate that to our …

… Although increasing evidence suggests that severe COVID-19 is an inflammatory disease
affecting many organs, the primary cause of COVID-19 is pulmonary viral replication, and …

… viral RNA-dependent RNA polymerase nsp12 drug interactions. Here, we examine the
molecular basis of SARS-CoV-2 RNA replication … of the coronavirus transcription and replication …

… , with special focus on SARS-CoV-2. We … SARS-CoV-2 replication and transcription. We
focus on the processes required for viral gene expression and replication: translation, replication …

… the viral replication. The capacity of the NO released from SNAP to covalently bind and inhibit
SARS-CoV… The observed reduction in SARS-CoV-2 protease activity was consistent with S-…

… RNA viruses that pose a major health risk 1 : SARS-CoV-2 … Coronaviruses use an RdRp
complex for the replication of their … The RdRp of SARS-CoV-2 is composed of a catalytic subunit …

… (ACE2), providing further evidence that SARSCoV originated in bats. … viral targets, such as
viral proteases, polymerases, and entry proteins have been identified to inhibit viral replication…

… 2 , but the viral proteins and the host factors involved remain unknown. Here we identify
the viral non-structural proteins (NSPs) that generate the SARS-CoV-2 replication organelle. …

… -nsp4 interaction eliminated viral replication by using an … of SARS-CoV. These findings
provide clues to the mechanism of the replication/transcription complex assembly of SARS-CoV …

… categories, those that can directly target the virus replication cycle, and those based on …
antiviral drug that interferes with the viral replication, and hydroxychloroquine, the repurposed …