… and stiffness coregulate tumor cell adhesion and migration beyond … cells translate and
respond to physical cues through mechanotransduction. Because of the critical role of tumor cell …

… on cells that receive stimuli from the TME. Physical cues—including rigid substrates or
forces such as solid stress, fluid shear stress, and tensile force—stimulate cancer cells and …

… consider the cancer cells and interstitial … physical changes, and could this help to achieve
a better prognosis?” In this work we focus on the following issues relevant to the “physical cues …

… Despite the well-established increase in IFP within breast tumors, our understanding of how
breast cancer cells respond to this physical stimulus remains elusive due to the scarcity of …

… adherence state may affect this particle uptake, as cells become stiffer when plated on a …
that cancer cells of the same origin, which are subjected to external mechanical cues through …

… and during critical stages of cancer cell dissemination from the … to these physical cues to
regulate cancer cell behavior during … overview of physical cues that cancer cells experience and …

… Two breast cancer cell lines were used in this research for the investigation of … cell homing
behavior and ECM microenvironments. Our results identify the homing cues of breast cancer, …

… cues from the microenvironment, physical cues can also greatly alter cellular behavior such
as proliferation, cancer stem cell … cells can work in concert with cancer cells to actively modify …

… This work first shows that metastatic ovarian cancer cells, which preferentially metastasize
to soft tissue, become more malignant on soft matrices by increasing adhesion, growth, …

… biophysical cues directly affect cancer cells, but also how do they affect tumor stromal cells,
such as cancer-associated fibroblasts or infiltrating immune cells such as macrophages. …