Predicting cancer cell invasion by single-cell physical phenotyping
The physical properties of cells are promising biomarkers for cancer diagnosis and
prognosis. Here we determine the physical phenotypes that best distinguish human cancer …
prognosis. Here we determine the physical phenotypes that best distinguish human cancer …
Multiparametric biomechanical and biochemical phenotypic profiling of single cancer cells using an elasticity microcytometer
Deep phenotyping of single cancer cells is of critical importance in the era of precision
medicine to advance understanding of relationships between gene mutation and cell …
medicine to advance understanding of relationships between gene mutation and cell …
Single-cell morphology encodes metastatic potential
A central goal of precision medicine is to predict disease outcomes and design treatments
based on multidimensional information from afflicted cells and tissues. Cell morphology is …
based on multidimensional information from afflicted cells and tissues. Cell morphology is …
Multiparameter mechanical and morphometric screening of cells
We introduce a label-free method to rapidly phenotype and classify cells purely based on
physical properties. We extract 15 biophysical parameters from cells as they deform in a …
physical properties. We extract 15 biophysical parameters from cells as they deform in a …
Quantitative deformability cytometry: rapid, calibrated measurements of cell mechanical properties
Advances in methods that determine cell mechanical phenotype, or mechanotype, have
demonstrated the utility of biophysical markers in clinical and research applications ranging …
demonstrated the utility of biophysical markers in clinical and research applications ranging …
Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines
V Swaminathan, K Mythreye, ET O'Brien, A Berchuck… - Cancer research, 2011 - AACR
Cancer cells are defined by their ability to invade through the basement membrane, a critical
step during metastasis. While increased secretion of proteases, which facilitates degradation …
step during metastasis. While increased secretion of proteases, which facilitates degradation …
Triangular correlation (TrC) between cancer aggressiveness, cell uptake capability, and cell deformability
Y Brill-Karniely, D Dror, T Duanis-Assaf, Y Goldstein… - Science …, 2020 - science.org
The malignancy potential is correlated with the mechanical deformability of the cancer cells.
However, mechanical tests for clinical applications are limited. We present here a Triangular …
However, mechanical tests for clinical applications are limited. We present here a Triangular …
Mechanomics biomarker for cancer cells unidentifiable through morphology and elastic modulus
Cellular mechanical properties are potential cancer biomarkers used for objective cytology
to replace the current subjective method relying on cytomorphology. However, heterogeneity …
to replace the current subjective method relying on cytomorphology. However, heterogeneity …
A deformability-based biochip for precise label-free stratification of metastatic subtypes using deep learning
Cellular deformability is a promising biomarker for evaluating the physiological state of cells
in medical applications. Microfluidics has emerged as a powerful technique for measuring …
in medical applications. Microfluidics has emerged as a powerful technique for measuring …
Altered physical phenotypes of leukemia cells that survive chemotherapy treatment
The recurrence of cancer following chemotherapy treatment is a major cause of death
across solid and hematologic cancers. In B-cell acute lymphoblastic leukemia (B-ALL) …
across solid and hematologic cancers. In B-cell acute lymphoblastic leukemia (B-ALL) …