This chapter shows important implications for the combined use of imaging analysis with
nanomechanical measurements as a novel biomarker for evaluating and sensing changes …

Recently biomechanics of cancer cells, in particular stiffness or elasticity, has been identified
as an important factor relating to cancer cell function, adherence, motility, transformation and …

Elastic clues in cancer detection | Nature Nanotechnology Skip to main content Thank you for
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The search for new cancer biomarkers is essential for fundamental research, diagnostics, as
well as for patient treatment and monitoring. Whereas most cancer biomarkers are …

The major characteristics of cancer metastasis is the ability of the primary tumor cells to
migrate by way of the blood or lymph vessels and to form tumors at multiple, distant sites …

Since the crucial role of the microenvironment has been highlighted, many studies have
been focused on the role of biomechanics in cancer cell growth and the invasion of the …

Many tumors, such as types of sarcoma and breast cancer, stiffen as they grow in a host
healthy tissue, while individual cancer cells are becoming softer. Tumor stiffening poses …

The stiffness of tumor cells varies during cancer progression. In particular, metastatic
carcinoma cells analyzed by Atomic Force Microscopy (AFM) appear softer than non …

Cancer development and progression are closely associated with changes both in the
mechano-cellular phenotype of cancer and stromal cells and in the extracellular matrix …

Traditionally, cell analysis has focused on using molecular biomarkers for basic research,
cell preparation, and clinical diagnostics; however, new microtechnologies are enabling …