We provide an innovative, bioengineering, mechanobiology-based approach to rapidly (2-h)
establish the in vivo metastatic likelihood of patient tumor-samples, where results are in …

Cancer mortality is mostly related to metastasis. Metastasis is currently prognosed via
histopathology, disease-statistics, or genetics; those are potentially inaccurate, not rapidly …

Non-melanoma skin cancers, including basal and squamous cell carcinomas (BCC and
SCC), are the most common malignancies worldwide. BCC/SCC cancers are generally …

We present a novel mechanobiology-based invasiveness assay to rapidly and quantitatively
evaluate the mechanical invasiveness of metastatic cancer cells and identify invasive …

We demonstrate the relative roles of the cell cytoskeleton, and specific importance of actin in
facilitating mechanical aspects of metastatic invasion. A crucial step in metastasis, the …

A critical step in metastases formation is cancer-cell invasion through tissue. During
invasion, cells change morphology and apply forces to their surroundings. We have …

This chapter shows important implications for the combined use of imaging analysis with
nanomechanical measurements as a novel biomarker for evaluating and sensing changes …

We show that cell-applied, normal mechanical stresses are required for cells to penetrate
into soft substrates, matching experimental observations in invasive cancer cells, while in …

The study of physical and mechanical features of cancer cells, or cancer cell
mechanobiology, is a new frontier in cancer research. Such studies may enhance our …

This chapter presents an overview of the process of cancer metastasis from a
mechanobiological perspective and provides a summary of current cytomechanobiology …