The recurrence of cancer following chemotherapy treatment is a major cause of death
across solid and hematologic cancers. In B-cell acute lymphoblastic leukemia (B-ALL) …

Cancers consist of a heterogeneous populations of cells that may respond differently to
treatment through drug-resistant sub-populations. The scarcity of these resistant sub …

To improve the survival rate of cancer patients, new diagnosis strategies are necessary to
detect lower levels of cancer cells before and after treatment regimens. The scarcity of …

We introduce a label-free method to rapidly phenotype and classify cells purely based on
physical properties. We extract 15 biophysical parameters from cells as they deform in a …

The physical properties of cells are promising biomarkers for cancer diagnosis and
prognosis. Here we determine the physical phenotypes that best distinguish human cancer …

Here we detail the design, fabrication, and use of a microfluidic device to evaluate the
deformability of a large number of individual cells in an efficient manner. Typically, data for …

The potential for circulating tumor cells (CTCs) to elucidate the process of cancer metastasis
and inform clinical decision-making has made their isolation of great importance. However …

Tumor heterogeneity is a primary factor that contributes to treatment failure. Predictive tools,
capable of classifying cancer cells based on their functions, may substantially enhance …

The role of cell mechanics in cancer cells is a novel research area that has resulted in the
identification of new mechanisms of therapy resistance. Single beam acoustic (SBA) …

Motivation Cancer cell heterogeneity can manifest genetically and phenotypically.
Bioinformatics methods have been used to analyze complex genomics and transcriptomics …