Intravital imaging of tumor cell motility in the tumor microenvironment context
B Bayarmagnai, L Perrin… - Cell Migration: Methods …, 2018 - Springer
Cancer cell motility and invasion are key features of metastatic tumors. Both are highly
linked to tumor microenvironmental parameters, such as collagen architecture or …
linked to tumor microenvironmental parameters, such as collagen architecture or …
Assessing micrometastases as a target for nanoparticles using 3D microscopy and machine learning
Metastasis of solid tumors is a key determinant of cancer patient survival. Targeting
micrometastases using nanoparticles could offer a way to stop metastatic tumor growth …
micrometastases using nanoparticles could offer a way to stop metastatic tumor growth …
[HTML][HTML] Physical biomarkers of disease progression: on-chip monitoring of changes in mechanobiology of colorectal cancer cells
Disease can induce changes to subcellular components, altering cell phenotype and
leading to measurable bulk-material mechanical properties. The mechanical phenotyping of …
leading to measurable bulk-material mechanical properties. The mechanical phenotyping of …
Cytoskeletal stiffness, friction, and fluidity of cancer cell lines with different metastatic potential
MF Coughlin, DR Bielenberg, G Lenormand… - Clinical & experimental …, 2013 - Springer
We quantified mechanical properties of cancer cells differing in metastatic potential. These
cells included normal and H-ras-transformed NIH3T3 fibroblast cells, normal and …
cells included normal and H-ras-transformed NIH3T3 fibroblast cells, normal and …
[HTML][HTML] Quantitative analyses of the tumor microenvironment composition and orientation in the era of precision medicine
F Petitprez, CM Sun, L Lacroix… - Frontiers in …, 2018 - frontiersin.org
Tumors are formed by aggregates of cells of various origins including malignant, stromal
and immune cells. The number of therapies targeting the microenvironment is increasing as …
and immune cells. The number of therapies targeting the microenvironment is increasing as …
In vitro 3D Models of Tunable Stiffness
EC Filipe, AL Parker, AL Cadell, G Major… - Metastasis: Methods and …, 2021 - Springer
Three-dimensional models of spheroid formation have been routinely used in the cancer
field to test the colony forming capacity of malignant cells in an in vitro setting. Use of such a …
field to test the colony forming capacity of malignant cells in an in vitro setting. Use of such a …
Biophysical informatics approach for quantifying phenotypic heterogeneity in cancer cell migration in confined microenvironments
X Zhang, M Mak - Bioinformatics, 2021 - academic.oup.com
Motivation Cancer cell heterogeneity can manifest genetically and phenotypically.
Bioinformatics methods have been used to analyze complex genomics and transcriptomics …
Bioinformatics methods have been used to analyze complex genomics and transcriptomics …
[HTML][HTML] In silico modelling of cancer nanomedicine, across scales and transport barriers
Nanoparticles promise to improve the treatment of cancer through their increasingly
sophisticated functionalisations and ability to accumulate in certain tumours. Yet recent work …
sophisticated functionalisations and ability to accumulate in certain tumours. Yet recent work …
A computational framework for identifying design guidelines to increase the penetration of targeted nanoparticles into tumors
Targeted nanoparticles are increasingly being engineered for the treatment of cancer. By
design, they can passively accumulate in tumors, selectively bind to targets in their …
design, they can passively accumulate in tumors, selectively bind to targets in their …
[图书][B] An introduction to physical oncology: How mechanistic mathematical modeling can improve cancer therapy outcomes
Physical oncology has the potential to revolutionize cancer research and treatment. The
fundamental rationale behind this approach is that physical processes, such as transport …
fundamental rationale behind this approach is that physical processes, such as transport …