The development of reliable predictive models for individual cancer cell lines to identify an
optimal cancer drug is a crucial step to accelerate personalized medicine, but vast …

Nanoparticles (NPs) are confronted with limited and disappointing delivery efficiency in
tumors clinically. The tumor extracellular matrix (ECM), whose physical traits have recently …

Simple Summary Cell migration is a key factor in the spread of metastatic tumors and a
major contributor to cancer-related mortality. However, our comprehension of the underlying …

Aggressive tumors of epithelial origin shed cells that intravasate and become circulating
tumor cells (CTC). The CTCs that are able to survive the stresses encountered in the …

Metastatic cancer has a poor prognosis, because it is broadly disseminated and associated
with both intrinsic and acquired drug resistance. Critical unmet needs in effectively killing …

A critical step in metastases formation is cancer-cell invasion through tissue. During
invasion, cells change morphology and apply forces to their surroundings. We have …

Targeted delivery of nanoparticle (NP)‐based diagnostic and therapeutic agents to
malignant cells and tissues has exclusively relied on chemotargeting, wherein NPs are …

The physics of mass transport within body compartments and across biological barriers
differentiates cancers from healthy tissues. Variants of nanoparticles can be manufactured in …

The challenge of predicting which patients with breast cancer will develop metastases leads
to the overtreatment of patients with benign disease and to the inadequate treatment of …

Recent developments in nanotechnology have brought new approaches to cancer
diagnosis and therapy. While enhanced permeability and retention effect (EPR) promotes …