Assays that can determine the response of tumor cells to cancer therapeutics could greatly
aid the selection of drug regimens for individual patients. However, the utility of current …

Cells can adapt their active contractile properties to switch between dynamical migratory
states and static homeostasis. Collective tissue surface tension, generated among others by …

Using a novel modeling approach based on the so-called environmental stress level (ESL),
we develop a mathematical model to describe systematically the collective influence of …

Highlights•Physical cues from the tumor microenvironment strongly affect cancer cell
behavior.•Novel techniques increasingly help to capture those cues in vitro.•Mechanisms for …

Cancer cells respond to matrix mechanical stiffness in a complex manner using a
coordinated, hierarchical mechano-chemical system composed of adhesion receptors and …

The aim of this Special Issue,“Nanoparticles for cancer therapy”, was to offer readers a
comprehensive and up-to-date insight into the various applications of nanoparticles in …

The microenvironment in a solid tumor includes a multitude of cell types, matrix proteins, and
growth factors that profoundly influence cancer cell mechanics by providing both physical …

Mechanics of cancer cells are directly linked to their metastatic potential, or ability to produce
a secondary tumor at a distant site. Metastatic cells survive in the circulatory system in a non …

Highlights⿢In vitro systems are needed to predict if, when, and where a tumor will
metastasize.⿢The ECM is a major driver of metastasis to specific tissue destinations.⿢ …

Cancer models relating basic science to clinical care in oncology may fail to address the
nuances of tumor behavior and therapy, as in the case, discussed herein, of the complex …