Triple-negative breast tumors are dependent on mutant p53 for growth and survival
D Dibra, SM Moyer, AK El-Naggar… - Proceedings of the …, 2023 - National Acad Sciences
The TP53 tumor suppressor gene is mutated early in the majority of patients with triple-
negative breast cancer (TNBC). The most frequent TP53 alterations are missense mutations …
negative breast cancer (TNBC). The most frequent TP53 alterations are missense mutations …
Triple-negative breast tumors are dependent on mutant p53 for growth and survival.
D Dibra, SM Moyer, AK El-Naggar, Y Qi… - Proceedings of the …, 2023 - europepmc.org
Results Mutant p53 R172H Drives Development of TNBCs. To study the role of mutant p53
in breast cancer, we used the somatic breast tumor model driven by a common hotspot …
in breast cancer, we used the somatic breast tumor model driven by a common hotspot …
Triple-negative breast tumors are dependent on mutant p53 for growth and survival
D Dibra, SM Moyer, AK El-Naggar… - Proceedings of the …, 2023 - pubmed.ncbi.nlm.nih.gov
The TP53 tumor suppressor gene is mutated early in the majority of patients with triple-
negative breast cancer (TNBC). The most frequent TP53 alterations are missense mutations …
negative breast cancer (TNBC). The most frequent TP53 alterations are missense mutations …
Triple-negative breast tumors are dependent on mutant p53 for growth and survival
D Dibra, SM Moyer… - … of the National …, 2023 - mdanderson.elsevierpure.com
The TP53 tumor suppressor gene is mutated early in the majority of patients with triple-
negative breast cancer (TNBC). The most frequent TP53 alterations are missense mutations …
negative breast cancer (TNBC). The most frequent TP53 alterations are missense mutations …
[HTML][HTML] Triple-negative breast tumors are dependent on mutant p53 for growth and survival
D Dibra, SM Moyer, AK El-Naggar, Y Qi… - Proceedings of the …, 2023 - ncbi.nlm.nih.gov
Results Mutant p53 R172H Drives Development of TNBCs. To study the role of mutant p53
in breast cancer, we used the somatic breast tumor model driven by a common hotspot …
in breast cancer, we used the somatic breast tumor model driven by a common hotspot …
Triple-negative breast tumors are dependent on mutant p53 for growth and survival
D Dibra, SM Moyer, AK El-Naggar… - Proceedings of the …, 2023 - ui.adsabs.harvard.edu
The physiological relevance of mutant p53 in tumor cell survival was studied in a mouse
model where mutant p53 can be toggled on and off genetically leaving the tumor …
model where mutant p53 can be toggled on and off genetically leaving the tumor …
Triple-negative breast tumors are dependent on mutant p53 for growth and survival.
D Dibra, SM Moyer, AK El-Naggar, Y Qi… - Proceedings of the …, 2023 - europepmc.org
The TP53 tumor suppressor gene is mutated early in the majority of patients with triple-
negative breast cancer (TNBC). The most frequent TP53 alterations are missense mutations …
negative breast cancer (TNBC). The most frequent TP53 alterations are missense mutations …