Cerium oxide nanoparticles trigger neuronal survival in a human Alzheimer disease model by modulating BDNF pathway

B D'Angelo, S Santucci, E Benedetti… - Current …, 2009 - ingentaconnect.com
… the effects of Cerium Oxide nanoparticles in protection of neuronal cells against cell death
induced by Alzheimer injury. We aim to confirm the hypothesis that Cerium Oxide, a rare earth …

The effect of cerium dioxide nanoparticles on the viability of hippocampal neurons in Alzheimer's disease modeling

VV Hanzha, NM Rozumna, YV Kravenska… - Frontiers in Cellular …, 2023 - frontiersin.org
neurons from neurodegeneration and promote their survival. … of AD pathogenesis in the
human brain. Second, we focused … function in AD animal models or humans. Further studies are …

Cerium oxide nanoparticles protect against Aβ-induced mitochondrial fragmentation and neuronal cell death

JM Dowding, W Song, K Bossy, A Karakoti… - Cell Death & …, 2014 - nature.com
… Moreover, peroxynitrite can trigger the release of free metals such … the function and survival
of rat spinal cord neurons exposed to … links neuronal ageing to sporadic Alzheimer's disease. …

Antibody-conjugated PEGylated cerium oxide nanoparticles for specific targeting of Aβ aggregates modulate neuronal survival pathways

A Cimini, B D'Angelo, S Das, R Gentile, E Benedetti… - Acta biomaterialia, 2012 - Elsevier
… bare cerium oxide nanoparticles in a human AD in vitro model. Protection of neurons against
… designed and formulated PEGylated cerium oxide nanoparticle-based molecules suitable …

Investigation of therapeutic potential of cerium oxide nanoparticles in Alzheimer's disease using transgenic Drosophila

V Sundararajan, GD Venkatasubbu, S Sheik Mohideen - 3 Biotech, 2021 - Springer
… in a human tau (htau) model of Alzheimer’s disease (AD), … pan-neuronal model (elav; htau)
of AD. Using an eye-specific … , is the first and major trigger for the subsequent damages that …

Cerium oxide nanoparticles: a 'radical'approach to neurodegenerative disease treatment

S Naz, J Beach, B Heckert, T Tummala… - …, 2017 - Taylor & Francis
… , including Alzheimer's disease, Parkinson's disease, multiple … examined its effect on neuronal
survival and the BDNF pathway … apoptotic effect of the disease in neuronal cells. They also …

[HTML][HTML] An overview on recent in vivo biological application of cerium oxide nanoparticles

BS Inbaraj, BH Chen - Asian journal of pharmaceutical sciences, 2020 - Elsevier
… in vivo studies of CNPs towards Alzheimer's disease, obesity, liver … neuronal death in 5XFAD
transgenic AD disease mouse … Excess ROS levels have been shown to trigger a series of …

Cerium oxide nanoparticles for the treatment of neurological oxidative stress diseases

AY Estevez, JS Erlichman - Oxidative Stress: Diagnostics …, 2011 - ACS Publications
… impact on protein activity and can trigger an immune response (49). … of ischemic neuronal
death and survival. J. Neurochem. … treatments and management of Alzheimer disease. Int. J. …

Advances in the study of cerium oxide nanoparticles: new insights into antiamyloidogenic activity

K Siposova, V Huntosova, Y Shlapa… - ACS Applied Bio …, 2019 - ACS Publications
… and in a variety of human diseases, such as cardiovascular … activate and regulate signaling
pathways as well as trigger … and destroying effect of cerium oxide nanoparticles on insulin …

Cerium oxide nanoparticles with antioxidant properties ameliorate strength and prolong life in mouse model of amyotrophic lateral sclerosis

W DeCoteau, KL Heckman, AY Estevez… - … , Biology and Medicine, 2016 - Elsevier
diseases, such as Alzheimer's disease and Parkinson's … neuronal morphology than they do
with the death of neurons. Thus, … CDDO, a triterpenoid that triggered endogenous antioxidant …