Genetic programs in human and mouse early embryos revealed by single-cell RNA sequencing

Z Xue, K Huang, C Cai, L Cai, C Jiang, Y Feng, Z Liu… - Nature, 2013 - nature.com
single-cell RNA sequencing has markedly improved transcriptome quantification of rare
human pre-implantation embryo … of gene activation, and genetic programming for early human

Defining the three cell lineages of the human blastocyst by single-cell RNA-seq

P Blakeley, NME Fogarty, I Del Valle… - …, 2015 - journals.biologists.com
reveals differences in human and mouse embryo gene … analyses of single-cell RNA-seq
datasets revealed a number of … -specific factors in human and mouse embryos. Our findings …

Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells

L Yan, M Yang, H Guo, L Yang, J Wu, R Li… - Nature structural & …, 2013 - nature.com
… the gene regulatory network controlling human embryonic … the transcriptome of human oocytes
and early embryos at … data set and the ones detected in our single-cell RNA-Seq data). (c) …

Tracing the first hematopoietic stem cell generation in human embryo by single-cell RNA sequencing

Y Zeng, J He, Z Bai, Z Li, Y Gong, C Liu, Y Ni, J Du… - Cell research, 2019 - nature.com
… scale gene expression landscape covering the entire course … transition (EHT) process in
human early embryos. Different cell … be detected in human embryos, we unexpectedly revealed

Single-cell RNA-seq reveals dynamic early embryonic-like programs during chemical reprogramming

T Zhao, Y Fu, J Zhu, Y Liu, Q Zhang, Z Yi, S Chen… - Cell stem cell, 2018 - cell.com
… identified a unique early embryonic-like gene network and epigenetic status as the key
molecular events that led to successful reprogramming. Finally, using the 2C-like program as an …

[HTML][HTML] Identification and functional analysis of long non-coding RNAs in human and mouse early embryos based on single-cell transcriptome data

J Qiu, Z Ren, J Yan - Oncotarget, 2016 - ncbi.nlm.nih.gov
… based on public single-cell RNA sequencing data. Expression profile analysis revealed that
… profiles and functions of lncRNAs in human early-stage embryos based on single-cell RNA

Single-cell RNA-seq reveals lineage and X chromosome dynamics in human preimplantation embryos

S Petropoulos, D Edsgärd, B Reinius, Q Deng… - Cell, 2016 - cell.com
… nucleotide polymorphisms (SNPs) in the single-cell RNA-seq reads, we observed that
most male E3 cells contained biallelically derived RNA of X chromosome genes (Figure 1D), …

Single-cell multi-omics sequencing of human early embryos

L Li, F Guo, Y Gao, Y Ren, P Yuan, L Yan, R Li… - Nature cell …, 2018 - nature.com
… 3d; RNA sequencing (RNA-seq) data were from a previous … , except for sperm, early embryos
showed clear species-… effects on gene expression in human early embryonic development. …

Light-induced injury in mouse embryos revealed by single-cell RNA sequencing

B Lv, C Liu, Y Chen, L Qi, L Wang, Y Ji, Z Xue - Biological Research, 2019 - Springer
… To further elucidate the mechanism underlying the response to lighting across preimplantation
embryonic stages, we performed gene ontology (GO) analysis on DEGs at each stage to …

Cell fate inclination within 2-cell and 4-cell mouse embryos revealed by single-cell RNA sequencing

FH Biase, X Cao, S Zhong - Genome research, 2014 - genome.cshlp.org
… blastomeres in early embryos (2-cell or 4-cell stage embryos) … embryo from single-cell RNA
sequencing (RNA-seq) data. … -embryo variation, we clustered all the detected genes. Large …