… gene expression profile of human one-cell embryos and relate it to development (Figure 1A).
Human … aged 22.5–31) and bipronuclear (2PN) one-cell embryos (n = 12, from six couples, …

Human embryonic genome activation initiates at the one-cell stage (Supplementary Tables) …

… [embryonic genome activation (EGA)] by activating … one-cell stage is small. Addressing
these challenges by scRNA-seq has shown that EGA initiates at the one-cell stage in humans [ …

… of embryonic transcription (embryonic genome activation [EGA]… expression (immediate
EGA [iEGA]) initiating within 4 h of … genome, and is mostly downregulated at the two-cell stage. …

… , the embryo does not acquire its own identity until it starts … one cell division 47, 48 and
humans begin transcribing their … Armed with this knowledge, we envision that the next phase of …

… embryos that have undergone spontaneous cleavage-stage … embryos that fail to appropriately
activate their genomes or … that CL2 embryos have independently initiated these essential …

… Y are also expressed in ZGA-stage 8-cell human embryos and may thus be relevant in vivo.
8CLCs provide a unique … Human embryonic genome activation initiates at the one-cell stage. …

… of zygotic gene activation (ZGA), are not detected until We have analyzed the spatial and …
We show that transcription at the 1-cell stage starts which allows us to detect incorporation …

… the 2-cell stage by maternally-provided zygotic genome-activating … to recruit transcription
factors initiating gene expression in … genome, it would be distributing zygotic genome activation …

… the 4-cell stage and contributed to the initiation of EGA, whereas … human one-cell embryos
are already transcriptionally competent; however, the majority of embryonic genome activation …