[PDF][PDF] α-Glucosidase and α-amylase inhibitory effect and antioxidant activity of ten plant extracts traditionally used in Iran for diabetes

P Salehi, B Asghari, MA Esmaeili, H Dehghan… - J. Med. Plants …, 2013 - academia.edu
J. Med. Plants Res, 2013academia.edu
Crataegus oxyacantha, Hibiscus sabdariffa, Morus alba, Portulaca oleracea, Rubus
fruticosus, Syzygium aromaticum, Teucrium polium, Trigonella foenum-graecum, and
Vaccinium arctostaphylos) were prepared using n-hexane, dichloromethane, chloroform,
ethyl acetate and methanol. Methanol, dichloromethane and n-hexane extracts of S.
aromaticum exerted high in vitro inhibitory potential against α-glucosidase and α-amylase
with IC50 ranging from 0.3 to 1.1 and 36.2 to 41.9 µg/ml, respectively. The mentioned …
Crataegus oxyacantha, Hibiscus sabdariffa, Morus alba, Portulaca oleracea, Rubus fruticosus, Syzygium aromaticum, Teucrium polium, Trigonella foenum-graecum, and Vaccinium arctostaphylos) were prepared using n-hexane, dichloromethane, chloroform, ethyl acetate and methanol. Methanol, dichloromethane and n-hexane extracts of S. aromaticum exerted high in vitro inhibitory potential against α-glucosidase and α-amylase with IC50 ranging from 0.3 to 1.1 and 36.2 to 41.9 µg/ml, respectively. The mentioned extracts possessed the highest total phenolic contents (139.8, 119.6 and 136.1 mg GAE/g of extract). The antioxidant activities of the extracts, measured in terms of IC50 values were 2.2, 3.9 and 0.7 µg/ml, respectively. C. zeylanicum was another traditionally used medicinal plant, which its extracts exhibited high hypoglycaemic effect by inhibition of α-glucosidase and α-amylase (IC50 ranged from 0.5 to 8.7 and 37.1 to 52.5 µg/ml, respectively). The obtained results support the traditionally use of a number of the analyzed species.
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