[HTML][HTML] β-Defensin 2 is a responsive biomarker of IL-17A–driven skin pathology in patients with psoriasis
F Kolbinger, C Loesche, MA Valentin, X Jiang… - Journal of Allergy and …, 2017 - Elsevier
Background IL-17A is a key driver of human autoimmune diseases, particularly psoriasis.
Objective We sought to determine the role of IL-17A in psoriasis pathogenesis and to identify
a robust and measurable biomarker of IL-17A–driven pathology. Methods We studied 8
healthy subjects and 8 patients with psoriasis before and after administration of
secukinumab, a fully human anti–IL-17A mAb, and used a combination of classical
techniques and a novel skin microperfusion assay to evaluate the expression of 170 …
Objective We sought to determine the role of IL-17A in psoriasis pathogenesis and to identify
a robust and measurable biomarker of IL-17A–driven pathology. Methods We studied 8
healthy subjects and 8 patients with psoriasis before and after administration of
secukinumab, a fully human anti–IL-17A mAb, and used a combination of classical
techniques and a novel skin microperfusion assay to evaluate the expression of 170 …