β-amyloid precursor protein is a direct cleavage target of HtrA2 serine protease: implications for the physiological function of HtrA2 in the mitochondria
HJ Park, SS Kim, YM Seong, KH Kim, HG Goo… - Journal of Biological …, 2006 - ASBMB
The processing and metabolism of amyloid precursor protein (APP) is a major interest in
Alzheimer disease (AD) research, because not only amyloid β (Aβ) peptide, but also cellular
or mitochondrial APP are intimately involved in cellular dysfunction and AD pathogenesis.
Here we demonstrate that APP is directly and efficiently cleaved by the HtrA2 serine
protease in vitro and in vivo. Using several APP mutants and N-terminal amino acid
sequencing, we identified that the HtrA2-mediated APP cleavage product is the C161 …
Alzheimer disease (AD) research, because not only amyloid β (Aβ) peptide, but also cellular
or mitochondrial APP are intimately involved in cellular dysfunction and AD pathogenesis.
Here we demonstrate that APP is directly and efficiently cleaved by the HtrA2 serine
protease in vitro and in vivo. Using several APP mutants and N-terminal amino acid
sequencing, we identified that the HtrA2-mediated APP cleavage product is the C161 …
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