Was comprehensively examined 48 patients with chronic Helicobacter pylori infection, which on the eve of the survey noted vomiting. It was found that 100% of the active form of HP infection were absent, and inactive forms were detected only in the stomach mucosa of the body in low concentrations. When tested for Helicobacter pylori (HP) in any way always, there are factors that affect their accuracy because of the impact on the active form of HP, so that bacteria becomes inactive forms. In the available literature, we found no evidence of the impact of such phenomena as vomiting, to active forms of HP, and that was the reason for our research. Was carried out a comprehensive survey of 48 patients with chronic Helicobacter pylori infection, which on the eve of the survey noted vomiting (age of the patients ranged from 18 to 56 years (mean age 35, 2±0, 95 years), there were 29 men (60, 4%), female-19 (39, 6%) of the time interval since the last prior to inspection emesis ranged from 1 to 2 days, the number of vomiting ranged from single to a multiple of 1 for x-days to 8 days) which included: intragastric pH-metry, esophagogastroduodenoscopy (EGD), double testing of HP infection (urease test and microscopy stained with Giemsa smears), biopsy material for which, as well as histological studies, was taken from the 4-topographical zones stomach: the middle third of the antrum and body of the stomach on the big and small curvature. The data obtained were processed statistically using the Student t-test with the calculation of the average values (M) and assessment of deviations (m). Changes were considered statistically significant at p< 0, 05. Hiperacid adequate level of acidity expressed in 9 (19%), moderate hiperacid-in 7 (15%), normacid-in 12 (25%), moderate hypoacid-in 9 (19%), hypoacid expressed-in 11 (22%) cases. During endoscopy in the 26 (54%) patients in the gastric lumen present bile in 4 (8%) were identified canker duodenal bulb under elementary and junior epithelialization, 11-minute (23%)-scar deformation of varying severity; organic and functional stenosis of the output of the duodenal bulb was out in 100% of cases. Histological studies have revealed a chronic inflammation of the body and antrum of the stomach in 100% of cases in the active or inactive form of varying severity. In the study on the active forms of HP infection of the gastric mucosa at 100% of the out and inactive only present in the stomach at low concentration (on a large curvature-1, 41±0, 29 (+), for low–1, 13±0, 29 (+)) with no significant difference (p> 0, 05). The data obtained can be interpreted in terms of impact on the bile of H. pylori infection. If vomiting occurs together with bile into the stomach and pancreatic juice flagged with pancreatic enzymes, which are active against a form has no way to protect themselves if the stomach enzymes against active form of HP infection is protected by alkalinity environment around him, then against pancreatic enzymes that are activated alkaline environment, this form of HP powerless that makes her go in protecting inactive form. If vomiting bile kontachit with mucous all parts of the stomach, which leads to the complete disappearance of the active forms. Vomit" wash" inactive forms of the narrow lumen antrum and most HP of the same shape of the body, which drastically reduces the degree of contamination of mucous HP infection due to its exit from the vomitus into the environment. In this situation, only microscopy stained smears mucosal biopsies taken from 4 areas of the stomach, allows testing the presence and concentration of HP infection.