The article contains the results of research of theoretical and methodological aspects of government regulation of enterprises of space industry in the conditions of political and economic instability in Ukraine, adoption of new politics of safety, state administration, economic politics of Ukraine, signing of Agreement about realization of the second stage of joining of Ukraine to the European space agency, development of new state standards adapted to the requirements of EU with taking into account of world requirements in relation to principle of conception sustainable development for the good of future generation. Structural constituents of government regulation of enterprises of space industry, methods and measures of realization of regulation with taking into account of tasks and features of development of enterprises of space industry are selected. There was given determination of process of government regulation of enterprises of space industry, and were indicated directions for improvement.