3-Amino-5-(indol-3-yl) methylene-4-oxo-2-thioxothiazolidine derivatives as antimicrobial agents: Synthesis, computational and biological evaluation

V Horishny, V Kartsev, V Matiychuk, A Geronikaki… - Pharmaceuticals, 2020 - mdpi.com
… )-3-morpholino-2-thioxothiazolidin-4-one derivatives the most important structural
features … On the other hand, in the series of indole 3-methylene morpholino-2-thioxothiazolidin-4-one

Synthesis of acetamides bearing 3-aryl-3, 4-dihydroquinazolin-4-one and 2-thioxothiazolidin-4-one moieties as novel derivatives

TC Nguyen, DD Pham, TMD Tran… - Vietnam Journal of …, 2022 - vietnamscience.vjst.vn
… of great interest in medicinal chemistry for their role as potential biological agents. These
derivatives exhibit a wide range of biological effects such as antimicrobial [13], antifungal [1], …

Design, synthesis, molecular modelling and antitumor evaluation of S-glucosylated rhodanines through topo II inhibition and DNA intercalation

AI Khodair, FM Alzahrani, MK Awad… - Journal of Enzyme …, 2023 - Taylor & Francis
… Surprisingly, the morpholinomethyl-2-thioxothiazolidin-4-one, inhibitor 10, was found
experimentally to be biological inactive which was confirmed from the calculated quantum …

Synthesis, characterization and DFT calculations of linear and NLO properties of novel (Z)-5-benzylidene-3-N (4-methylphenyl)-2-thioxothiazolidin-4-one

T Bensafi, D Hadji, A Yahiaoui, K Argoub… - Journal of Sulfur …, 2021 - Taylor & Francis
… In this study, the bandgap energy of (Z)-5-benzylidene-3-N(4-methylphenyl)-2-thioxothiazolidin-4-one
is determined from the UV–VIS-spectrum shown in Figure 1 . A maximum …

A brief literature and review of patents on thiazole related derivatives

D Sharma, KK Bansal, A Sharma… - … Compounds, 2019 - ingentaconnect.com
2-Thioxothiazolidin-4-one compounds and compositions as antimicrobial and antimalarial
agents targeting enoyl-ACP reductase of type II fatty acid. US Patent 0,051,445, A1, Feb 28, …

New Hybrid Tetrahydropyrrolo[3,2,1-ij]quinolin-1-ylidene-2-thioxothiazolidin-4-ones as New Inhibitors of Factor Xa and Factor XIa: Design, Synthesis, and In Silico …

NP Novichikhina, AS Shestakov, SM Medvedeva… - Molecules, 2023 - mdpi.com
… The in vitro testing showed that eight derivatives are capable of inhibiting both coagulation
factors, two compounds are selective inhibitors of factor Xa, and two compounds are selective …

… of novel indolin-2-one derivative incorporating thiazole moiety as DHFR and quorum sensing inhibitors: Synthesis, antimicrobial, and antibiofilm activities with …

AY Alzahrani, YA Ammar, M Abu-Elghait, MA Salem… - Bioorganic …, 2022 - Elsevier
… The IR spectrum of 3-methyl-5-(2-oxoindolin-3-ylidene)-2-thioxothiazolidin-4-one 5a
revealed absorption bands at υ 3118, 1702, and 1694 cm −1 corresponding to NH and two …

Drug screening of rhodanine derivatives for antibacterial activity

S Maddila, S Gorle… - Expert Opinion on Drug …, 2020 - Taylor & Francis
… A novel series of 3-(4-chlorophenyl)-5-((1-phenyl-3-aryl-1H-pyrazol-4-yl) methylene)-2-thioxothiazolidin-4-one
molecules were synthesized and screened for their in vitro antibacterial

Antiplasmodial drug targets: A patent review (2000–2013)

J Okombo, K Chibale - Expert Opinion on Therapeutic Patents, 2016 - Taylor & Francis
… only address antimalarial drug design. More … antimicrobial and antimalarial agents against
this protein – either alone or in combination with other known antimicrobial/antimalarial agents

Biological activities of guanidine compounds, 2008–2012 update

F Sączewski, Ł Balewski - Expert opinion on therapeutic patents, 2013 - Taylor & Francis
… Novel 2-thioxothiazolidin-4-one derivatives 58 ( Figure 23 ) are … Disclosed are also compounds
having polybasic … are used in combination with an antibacterial agent to treat or prevent …