3D molecular imaging SIMS

G Gillen, A Fahey, M Wagner, C Mahoney - Applied surface science, 2006 - Elsevier
… pharmaceuticals have been analyzed by dynamic SIMS using SF 5 + polyatomic primary ion
… The bevel surface can then be examined using cluster SIMS imaging or other appropriate …

A new SIMS paradigm for 2D and 3D molecular imaging of bio-systems

JS Fletcher, JC Vickerman - Analytical and bioanalytical chemistry, 2010 - Springer
… aspiration has yet to be reached for molecular imaging. This brief review shows that using
… will restrict useful imaging to around 2 μm spatial resolution with high-yield molecules. The …

On the road to high-resolution 3D molecular imaging

A Delcorte - Applied Surface Science, 2008 - Elsevier
… way to 3D molecular imaging in SIMS, such as ultimate lateral resolution, limited molecular
yields, … currently in embryo in the many research teams concerned by 3D molecular imaging. …

Developments in molecular SIMS depth profiling and 3D imaging of biological systems using polyatomic primary ions

JS Fletcher, NP Lockyer… - Mass spectrometry …, 2011 - Wiley Online Library
… -SIMS analysis will be discussed with particular emphasis on how these are exacerbated
when seeking to exploit the particularly attractive 2D and 3D molecular imaging capabilities of …

SIMS of organics—Advances in 2D and 3D imaging and future outlook

IS Gilmore - Journal of Vacuum Science & Technology A, 2013 - pubs.aip.org
… in the conjugated polymers and molecules used. Figure 13 shows the 3D molecular image
of one pixel from an organic electronic display. The image shows the multiple organic layers …

Cryo-OrbiSIMS for 3D molecular imaging of a bacterial biofilm in its native state

J Zhang, J Brown, DJ Scurr, A Bullen… - Analytical …, 2020 - ACS Publications
… Secondary ion mass spectrometry (SIMS) is gaining popularity for molecular imaging in
the life sciences because it is label-free and allows imaging in two and three dimensions. The …

[HTML][HTML] Latest applications of 3D ToF-SIMS bio-imaging

JS Fletcher - Biointerphases, 2015 - pubs.aip.org
… spectrometry (SIMS) is capable of such analysis and 3D molecular imaging using SIMS is
… -of-flight (ToF)-SIMS that have allowed 3D molecular imaging to be realized with illustrative …

Bioimaging TOF‐SIMS: High resolution 3D imaging of single cells

H Nygren, B Hagenhoff, PER Malmberg… - Microscopy research …, 2007 - Wiley Online Library
… was analyzed by imaging TOF-SIMS. Repeated sputtering … , and analyzed by 3D-imaging
TOF-SIMS. Indeed, membrane … compartments can be visualized by 3D imaging TOF-SIMS. …

[PDF][PDF] 3D chemical image using TOF‐SIMS revealing the biopolymer component spatial and lateral distributions in biomass

S Jung, M Foston, UC Kalluri, GA Tuskan… - Angewandte …, 2012 - academia.edu
… TOF-SIMS is an … molecular image representing the lateral distribution of characteristic
species at a submicrometer scale. Extending the usefulness of TOFSIMS, a 3D molecular image

Mass spectrometry imaging and integration with other imaging modalities for greater molecular understanding of biological tissues

T Porta Siegel, G Hamm, J Bunch, J Cappell… - Molecular imaging and …, 2018 - Springer
… The combination of MSI with other molecular imaging techniques can also provide highly
relevant complementary information to explore new scientific fields. Traditionally, classical …