The paper reports the main results of the EU project Millennium in the Mediterranean area over the last 500 years. It analyses a long series of temperature from Portugal, Spain, France, Italy and Greece. The series are obtained by combining indices from documentary sources from AD 1500 to the onset of regular instrumental observations. There is an ongoing discussion regarding the proper way of combining documentary and instrumental data and how to translate accurately the conventional indices from − 3 to + 3 into modern units, i.e. degree Celsius. This paper produces for the first time a number of early instrumental observations, in some cases (i.e. Italy and France) covering 350 years, including thereby the earliest regular observations after the invention of the thermometer. These Mediterranean data show that anomalous temperatures usually had only a locally limited effect, while only few extreme events had a widespread impact over the whole region, such as the summer of 2003. During the period from 1850 to the present day, the Mediterranean temperature anomaly was close to the Northern Hemisphere in spring and summer, while it was warmer in autumn and winter. Compared with the long-term instrumental records (i.e. 1655 onwards), the recent warming has not exceeded the natural past variability characterized by heating–cooling cycles with no significant long-term trends.